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Target
Vasopressin V2 receptor
Ligand
BDBM50020655
Substrate
n/a
Meas. Tech.
ChEMBL_215034 (CHEMBL820884)
Ki
4.60±n/a nM
Citation
 Huffman, WF; Ali, FE; Bryan, WM; Callahan, JF; Moore, ML; Silvestri, JS; Yim, NC; Kinter, LB; McDonald, JE; Ashton-Shue, D Novel vasopressin analogues that help define a minimum effective antagonist pharmacophore. J Med Chem 28:1759-60 (1986) [PubMed]  Article 
Target
Name:
Vasopressin V2 receptor
Synonyms:
AVPR2 | V2R_PIG
Type:
PROTEIN
Mol. Mass.:
40556.17
Organism:
Sus scrofa
Description:
ChEMBL_214870
Residue:
370
Sequence:
MLRATTSAVPRALSWPAAPGNGSEREPLDDRDPLLARVELALLSTVFVAVALSNGLVLGALVRRGRRGRWAPMHVFIGHLCLADLAVALFQVLPQLAWDATYRFRGPDALCRAVKYLQMVGMYASSYMILAMTLDRHRAICRPMLAYRHGGGARWNRPVLVAWAFSLLLSLPQLFIFAQRDVGDGSGVLDCWASFAEPWGLRAYVTWIALMVFVAPALGIAACQVLIFREIHTSLVPGPAERAGGHRGGRRAGSPREGARVSAAMAKTARMTLVIVAVYVLCWAPFFLVQLWSVWDPKAPREGPPFVLLMLLASLNSCTNPWIYASFSSSISSELRSLLCCPRRRTPPSLRPQEESCATASSFSARDTSS
  
Inhibitor
Name:
BDBM50020655
Synonyms:
CHEMBL408474 | [6-Amino-2-({1-[19-amino-13-benzyl-10-(2-carbamoyl-ethyl)-7-carbamoylmethyl-16-(4-hydroxy-benzyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentaaza-cycloicosane-4-carbonyl]-pyrrolidine-2-carbonyl}-amino)-hexanoylamino]-acetic acid
Type:
Small organic molecule
Emp. Form.:
C46H64N12O13S2
Mol. Mass.:
1057.203
SMILES:
NCCCC[C@H](NC(=O)[C@H]1CCCN1C(=O)[C@@H]1CSSC[C@@H](N)C(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1)C(=O)NCC(O)=O
Structure:
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