Reaction Details Report a problem with these data
Target
P2Y purinoceptor 14
Ligand
BDBM50456168
Substrate
n/a
Meas. Tech.
ChEMBL_1755230 (CHEMBL4189990)
Ki
0.400000±n/a nM
Citation
 Yu, J; Ciancetta, A; Dudas, S; Duca, S; Lottermoser, J; Jacobson, KA Structure-Guided Modification of Heterocyclic Antagonists of the P2Y J Med Chem 61:4860-4882 (2018) [PubMed]  Article 
Target
Name:
P2Y purinoceptor 14
Synonyms:
G-protein coupled receptor 105 | Gpr105 | P2Y purinoceptor 14 | P2Y14 | P2Y14_RAT | P2ry14 | UDP-glucose receptor | VTR 15-20
Type:
PROTEIN
Mol. Mass.:
34820.08
Organism:
Rattus norvegicus
Description:
ChEMBL_117905
Residue:
305
Sequence:
MDNTTTTEPPKQPCTRNTLITQQIIPMLYCVVFITGVLLNGISGWIFFYVPSSKSFIIYLKNIVVADFLMGLTFPFKVLSDSGLGPWQLNVFVFRVSAVIFYVNMYVSIAFFGLISFDRYYKIVKPLLVSIVQSVNYSKVLSVLVWVLMLLLAVPNIILTNQSVKDVTNIQCMELKNELGRKWHKASNYVFVSIFWIVFLLLTVFYMAITRKIFKSHLKSRKNSISVKRKSSRNIFSIVLAFVACFAPYHVARIPYTKSQTEGHYSCQAKETLLYTKEFTLLLSAANVCLDPISISSYASRLEKS
  
Inhibitor
Name:
BDBM50456168
Synonyms:
CHEMBL1800685
Type:
Small organic molecule
Emp. Form.:
C29H24F3NO2
Mol. Mass.:
475.5016
SMILES:
OC(=O)c1cc(-c2ccc(cc2)C2CCNCC2)c2ccc(cc2c1)-c1ccc(cc1)C(F)(F)F
Structure:
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