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Target
Alpha-crystallin B chain
Ligand
BDBM50459236
Substrate
n/a
Meas. Tech.
ChEMBL_1765952 (CHEMBL4201199)
EC50
3116±n/a nM
Citation
 Yang, X; Chen, XJ; Yang, Z; Xi, YB; Wang, L; Wu, Y; Yan, YB; Rao, Y Synthesis, Evaluation, and Structure-Activity Relationship Study of Lanosterol Derivatives To Reverse Mutant-Crystallin-Induced Protein Aggregation. J Med Chem 61:8693-8706 (2018) [PubMed]  Article 
Target
Name:
Alpha-crystallin B chain
Synonyms:
Alpha(B)-crystallin | Alpha-crystallin B chain | CRYA2 | CRYAB | CRYAB_HUMAN | HSPB5 | Heat shock protein beta-5 | Renal carcinoma antigen NY-REN-27 | Rosenthal fiber component
Type:
PROTEIN
Mol. Mass.:
20162.17
Organism:
Homo sapiens
Description:
ChEMBL_109886
Residue:
175
Sequence:
MDIAIHHPWIRRPFFPFHSPSRLFDQFFGEHLLESDLFPTSTSLSPFYLRPPSFLRAPSWFDTGLSEMRLEKDRFSVNLDVKHFSPEELKVKVLGDVIEVHGKHEERQDEHGFISREFHRKYRIPADVDPLTITSSLSSDGVLTVNGPRKQVSGPERTIPITREEKPAVTAAPKK
  
Inhibitor
Name:
BDBM50459236
Synonyms:
CHEMBL4203007
Type:
Small organic molecule
Emp. Form.:
C30H52O2
Mol. Mass.:
444.7327
SMILES:
[H][C@@]1(CC[C@@]2(C)C3=C(CC[C@]12C)[C@@]1(C)CC[C@H](O)C(C)(C)[C@]1([H])CC3)[C@H](C)CCCC(C)(C)O |r,c:6|
Structure:
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