| Reaction Details |
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 | Report a problem with these data |
| Target | Renin |
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| Ligand | BDBM50022869 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_195945 |
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| pH | 6±n/a |
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| IC50 | 1500±n/a nM |
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| Comments | extracted |
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| Citation |  Luly, JR; Bolis, G; BaMaung, N; Soderquist, J; Dellaria, JF; Stein, H; Cohen, J; Perun, TJ; Greer, J; Plattner, JJ New inhibitors of human renin that contain novel Leu-Val replacements. Examination of the P1 site. J Med Chem31:532-9 (1988) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| |
| Renin |
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| Name: | Renin |
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| Synonyms: | Angiotensinogenase |
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| Type: | Enzyme |
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| Mol. Mass.: | 45058.99 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 406 |
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| Sequence: | MDGWRRMPRWGLLLLLWGSCTFGLPTDTTTFKRIFLKRMPSIRESLKERGVDMARLGPEW
SQPMKRLTLGNTTSSVILTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRL
YTACVYHKLFDASDSSSYKHNGTELTLRYSTGTVSGFLSQDIITVGGITVTQMFGEVTEM
PALPFMLAEFDGVVGMGFIEQAIGRVTPIFDNIISQGVLKEDVFSFYYNRDSENSQSLGG
QIVLGGSDPQHYEGNFHYINLIKTGVWQIQMKGVSVGSSTLLCEDGCLALVDTGASYISG
STSSIEKLMEALGAKKRLFDYVVKCNEGPTLPDISFHLGGKEYTLTSADYVFQESYSSKK
LCTLAIHAMDIPPPTGPTWALGATFIRKFYTEFDRRNNRIGFALAR
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| BDBM50022869 |
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| Name | BDBM50022869 |
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| Synonyms: | 1N-[1-[1-(2-cyclohexylethyl)-2-hydroxy-3-isopropylsulfanyl-(1S,2R)-propylcarbamoyl]-2-(1H-5-imidazolyl)-(1S)-ethyl]-2-amino-tertiarybutyloxycarbonyl-3-phenyl-(2S)-propanamide | CHEMBL347741 |
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| Type | Small organic molecule |
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| Emp. Form. | C34H53N5O5S |
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| Mol. Mass. | 643.88 |
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| SMILES | CC(C)SC[C@H](O)[C@H](CCC1CCCCC1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](Cc1ccccc1)NC(=O)OC(C)(C)C |
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| Structure | 
|
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| n/a |
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