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TargetRenin
LigandBDBM50023092
Substrate/Competitorn/a
Meas. Tech.ChEMBL_196264
Ki 28±n/a nM
Citation Bock, MGDiPardo, RMEvans, BERittle, KEBoger, JPoe, MLaMont, BILynch, RJUlm, EHVlasuk, GP Renin inhibitors. Statine-containing tetrapeptides with varied hydrophobic carboxy termini. J Med Chem30:1853-7 (1987) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Renin
Name:Renin
Synonyms:Angiotensinogenase
Type:Enzyme
Mol. Mass.:45058.99
Organism:Homo sapiens (Human)
Description:n/a
Residue:406
Sequence:
MDGWRRMPRWGLLLLLWGSCTFGLPTDTTTFKRIFLKRMPSIRESLKERGVDMARLGPEW
SQPMKRLTLGNTTSSVILTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRL
YTACVYHKLFDASDSSSYKHNGTELTLRYSTGTVSGFLSQDIITVGGITVTQMFGEVTEM
PALPFMLAEFDGVVGMGFIEQAIGRVTPIFDNIISQGVLKEDVFSFYYNRDSENSQSLGG
QIVLGGSDPQHYEGNFHYINLIKTGVWQIQMKGVSVGSSTLLCEDGCLALVDTGASYISG
STSSIEKLMEALGAKKRLFDYVVKCNEGPTLPDISFHLGGKEYTLTSADYVFQESYSSKK
LCTLAIHAMDIPPPTGPTWALGATFIRKFYTEFDRRNNRIGFALAR
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50023092
NameBDBM50023092
Synonyms:Boc-Phe-His-Sta-Leu-(+)-1,2-diphenylthylamide | Boc-Phe-His-Sta-Leu-(-)-1,2-diphenylthylamide | Boc-Phe-His-Sta-Leu-(-)-alpha-phenylthylamide | CHEMBL53112
TypeSmall organic molecule
Emp. Form.C48H65N7O7
Mol. Mass.852.0724
SMILESCC(C)CC(NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](Cc1ccccc1)NC(=O)OC(C)(C)C)C(O)CC(=O)N[C@@H](CC(C)C)C(=O)NC(Cc1ccccc1)c1ccccc1
Structure
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n/a