Reaction Details Report a problem with these data
Target
Renin
Ligand
BDBM50023088
Substrate
n/a
Meas. Tech.
ChEMBL_196265 (CHEMBL803242)
Ki
100±n/a nM
Citation
 Bock, MG; DiPardo, RM; Evans, BE; Rittle, KE; Boger, J; Poe, M; LaMont, BI; Lynch, RJ; Ulm, EH; Vlasuk, GP Renin inhibitors. Statine-containing tetrapeptides with varied hydrophobic carboxy termini. J Med Chem 30:1853-7 (1987) [PubMed]  Article 
Target
Name:
Renin
Synonyms:
Angiotensinogenase | REN | RENI_HUMAN
Type:
Enzyme
Mol. Mass.:
45058.99
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
406
Sequence:
MDGWRRMPRWGLLLLLWGSCTFGLPTDTTTFKRIFLKRMPSIRESLKERGVDMARLGPEWSQPMKRLTLGNTTSSVILTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRLYTACVYHKLFDASDSSSYKHNGTELTLRYSTGTVSGFLSQDIITVGGITVTQMFGEVTEMPALPFMLAEFDGVVGMGFIEQAIGRVTPIFDNIISQGVLKEDVFSFYYNRDSENSQSLGGQIVLGGSDPQHYEGNFHYINLIKTGVWQIQMKGVSVGSSTLLCEDGCLALVDTGASYISGSTSSIEKLMEALGAKKRLFDYVVKCNEGPTLPDISFHLGGKEYTLTSADYVFQESYSSKKLCTLAIHAMDIPPPTGPTWALGATFIRKFYTEFDRRNNRIGFALAR
  
Inhibitor
Name:
BDBM50023088
Synonyms:
Boc-Phe-His-Sta-Leu-p-methoxybenzylamide | CHEMBL54886
Type:
Small organic molecule
Emp. Form.:
C42H61N7O8
Mol. Mass.:
791.9758
SMILES:
COc1ccc(CNC(=O)[C@H](CC(C)C)NC(=O)CC(O)C(CC(C)C)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H](Cc2ccccc2)NC(=O)OC(C)(C)C)cc1
Structure:
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