Reaction Details Report a problem with these data
Target
Nuclear receptor ROR-beta
Ligand
BDBM50460728
Substrate
n/a
Meas. Tech.
ChEMBL_1770184 (CHEMBL4222296)
IC50
160±n/a nM
Citation
 Patouret, R; Doebelin, C; Garcia-Ordonez, RD; Chang, MR; Ruiz, C; Cameron, MD; Griffin, PR; Kamenecka, TM Identification of an aminothiazole series of ROR? modulators. Bioorg Med Chem Lett 28:1178-1181 (2018) [PubMed]  Article 
Target
Name:
Nuclear receptor ROR-beta
Synonyms:
NR1F2 | Nuclear receptor RZR-beta | Nuclear receptor subfamily 1 group F member 2 | RORB | RORB_HUMAN | RZRB | Retinoid-related orphan receptor-beta
Type:
PROTEIN
Mol. Mass.:
53227.30
Organism:
Homo sapiens (Human)
Description:
ChEMBL_107979
Residue:
470
Sequence:
MCENQLKTKADATAQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQNNASYSCPRQRNCLIDRTNRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLYAEVQKHQQRLQEQRQQQSGEAEALARVYSSSISNGLSNLNNETSGTYANGHVIDLPKSEGYYNVDSGQPSPDQSGLDMTGIKQIKQEPIYDLTSVPNLFTYSSFNNGQLAPGITMTEIDRIAQNIIKSHLETCQYTMEELHQLAWQTHTYEEIKAYQSKSREALWQQCAIQITHAIQYVVEFAKRITGFMELCQNDQILLLKSGCLEVVLVRMCRAFNPLNNTVLFEGKYGGMQMFKALGSDDLVNEAFDFAKNLCSLQLTEEEIALFSSAVLISPDRAWLIEPRKVQKLQEKIYFALQHVIQKNHLDDETLAKLIAKIPTITAVCNLHGEKLQVFKQSHPEIVNTLFPPLYKELFNPDCATGCK
  
Inhibitor
Name:
BDBM50460728
Synonyms:
CHEMBL4227867
Type:
Small organic molecule
Emp. Form.:
C18H12BrF3N2O2S
Mol. Mass.:
457.264
SMILES:
COc1ccccc1C(=O)c1sc(N)nc1-c1cc(Br)cc(c1)C(F)(F)F
Structure:
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