Target
Sterol O-acyltransferase 1
Ligand
BDBM50033969
Substrate
n/a
Meas. Tech.
ChEMBL_1776178 (CHEMBL4233170)
IC50
1000±n/a nM
Citation
 Shibuya, KKawamine, KMiura, TOzaki, CEdano, TMizuno, KYoshinaka, YTsunenari, Y Design, synthesis and pharmacology of aortic-selective acyl-CoA: Cholesterol O-acyltransferase (ACAT/SOAT) inhibitors. Bioorg Med Chem 26:4001-4013 (2018) [PubMed]  Article 
Target
Name:
Sterol O-acyltransferase 1
Synonyms:
ACAT-1 | Acact | Acetoacetyl-CoA thiolase | Acetyl-CoA acetyltransferase, mitochondrial | Acyl coenzyme A:cholesterol acyltransferase 1 | Acyl-coenzyme A:cholesterol acyltransferase 1 | Cholesterol acyltransferase 1 | SOAT1_MOUSE | Soat1 | Sterol O-acyltransferase 1
Type:
PROTEIN
Mol. Mass.:
63818.83
Organism:
Mus musculus
Description:
ChEMBL_90523
Residue:
540
Sequence:
MSLRNRLSKSGENPEQDEAQKNFMDTYRNGHITMKQLIAKKRLLAAEAEELKPLFMKEVGCHFDDFVTNLIEKSASLDNGGCALTTFSILEEMKKNHRAKDLRAPPEQGKIFISRQSLLDELFEVDHIRTIYHMFIALLILFVLSTIVVDYIDEGRLVLEFNLLAYAFGKFPTVIWTWWAMFLSTLSIPYFLFQRWAHGYSKSSHPLIYSLVHGLLFLVFQLGVLGFVPTYVVLAYTLPPASRFILILEQIRLIMKAHSFVRENIPRVLNAAKEKSSKDPLPTVNQYLYFLFAPTLIYRDNYPRTPTVRWGYVAMQFLQVFGCLFYVYYIFERLCAPLFRNIKQEPFSARVLVLCVFNSILPGVLILFLSFFAFLHCWLNAFAEMLRFGDRMFYKDWWNSTSYSNYYRTWNVVVHDWLYYYVYKDLLWFFSKRFKSAAMLAVFALSAVVHEYALAICLSYFYPVLFVLFMFFGMAFNFIVNDSRKRPIWNIMVWASLFLGYGLILCFYSQEWYARQHCPLKNPTFLDYVRPRTWTCRYVF
  
Inhibitor
Name:
BDBM50033969
Synonyms:
3-(2,4-Difluoro-phenyl)-1-[5-(4,5-diphenyl-1H-imidazol-2-ylsulfanyl)-pentyl]-1-heptyl-urea | CHEMBL274185 | Lecimibide
Type:
Small organic molecule
Emp. Form.:
C34H40F2N4OS
Mol. Mass.:
590.769
SMILES:
CCCCCCCN(CCCCCSc1nc(c([nH]1)-c1ccccc1)-c1ccccc1)C(=O)Nc1ccc(F)cc1F
Structure:
Search PDB for entries with ligand similarity: