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Target
HLA class I histocompatibility antigen, A alpha chain
Ligand
BDBM19441
Substrate
n/a
Meas. Tech.
ChEMBL_1778180 (CHEMBL4235172)
Kd
22000±n/a nM
Citation
 Ren, J; Dsouza, NR; Deng, H; Lee, H; Bouvier, M; Johnson, ME Discovery of small molecule inhibitors of adenovirus by disrupting E3-19K/HLA-A2 interactions. Bioorg Med Chem Lett 28:2837-2841 (2018) [PubMed]  Article 
Target
Name:
HLA class I histocompatibility antigen, A alpha chain
Synonyms:
HLA class I histocompatibility antigen A-3 | HLA class I histocompatibility antigen, A-3 alpha chain | HLA-A | HLAA | HLAA_HUMAN | MHC class I antigen A*3
Type:
PROTEIN
Mol. Mass.:
40836.72
Organism:
Homo sapiens (Human)
Description:
ChEMBL_47858
Residue:
365
Sequence:
MAVMAPRTLLLLLSGALALTQTWAGSHSMRYFFTSVSRPGRGEPRFIAVGYVDDTQFVRFDSDAASQRMEPRAPWIEQEGPEYWDQETRNVKAQSQTDRVDLGTLRGYYNQSEAGSHTIQIMYGCDVGSDGRFLRGYRQDAYDGKDYIALNEDLRSWTAADMAAQITKRKWEAAHEAEQLRAYLDGTCVEWLRRYLENGKETLQRTDPPKTHMTHHPISDHEATLRCWALGFYPAEITLTWQRDGEDQTQDTELVETRPAGDGTFQKWAAVVVPSGEEQRYTCHVQHEGLPKPLTLRWELSSQPTIPIVGIIAGLVLLGAVITGAVVAAVMWRRKSSDRKGGSYTQAASSDSAQGSDVSLTACKV
  
Inhibitor
Name:
BDBM19441
Synonyms:
2-(4-hydroxyphenyl)-3-({4-[2-(piperidin-1-yl)ethoxy]phenyl}carbonyl)-1-benzothiophen-6-ol | CHEMBL81 | Evista | Keoxifene | RALOXIFENE HYDROCHLORIDE | Raloxifene | Raloxifene (7) | Raloxifene, 6 | [6-hydroxy-2-(4-hydroxyphenyl)-1-benzothiophen-3-yl]-[4-(2-piperidin-1-ylethoxy)phenyl]methanone | cid_11071264
Type:
Small organic molecule
Emp. Form.:
C28H27NO4S
Mol. Mass.:
473.583
SMILES:
Oc1ccc(cc1)-c1sc2cc(O)ccc2c1C(=O)c1ccc(OCCN2CCCCC2)cc1
Structure:
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