Target
Alcohol dehydrogenase class-3
Ligand
BDBM50465810
Substrate
n/a
Meas. Tech.
ChEMBL_1788804 (CHEMBL4260538)
IC50
20±n/a nM
Citation
 Muthukaman, NDeshmukh, STondlekar, STambe, MPisal, DSarode, NMhatre, SChakraborti, SShah, DBhosale, VMKulkarni, AMahat, MYAJadhav, SBGudi, GSKhairatkar-Joshi, NGharat, LA Discovery of 5-(2-chloro-4'-(1H-imidazol-1-yl)-[1,1'-biphenyl]-4-yl)-1H-tetrazole as potent and orally efficacious S-nitrosoglutathione reductase (GSNOR) inhibitors for the potential treatment of COPD. Bioorg Med Chem Lett 28:3766-3773 (2018) [PubMed]  Article 
Target
Name:
Alcohol dehydrogenase class-3
Synonyms:
1.1.1.- | 1.1.1.1 | 1.1.1.284 | ADH5 | ADHX | ADHX_HUMAN | Alcohol dehydrogenase 5 | Alcohol dehydrogenase class chi chain | Alcohol dehydrogenase class-3 | Alcohol dehydrogenase class-III | FALDH | FDH | Glutathione-dependent formaldehyde dehydrogenase (GSH-FDH) | S-nitrosoglutathione reductase (GSNOR) | alcohol dehydrogenase 3 (ADH-3)
Type:
n/a
Mol. Mass.:
39728.34
Organism:
Homo sapiens (Human)
Description:
P11766
Residue:
374
Sequence:
MANEVIKCKAAVAWEAGKPLSIEEIEVAPPKAHEVRIKIIATAVCHTDAYTLSGADPEGCFPVILGHEGAGIVESVGEGVTKLKAGDTVIPLYIPQCGECKFCLNPKTNLCQKIRVTQGKGLMPDGTSRFTCKGKTILHYMGTSTFSEYTVVADISVAKIDPLAPLDKVCLLGCGISTGYGAAVNTAKLEPGSVCAVFGLGGVGLAVIMGCKVAGASRIIGVDINKDKFARAKEFGATECINPQDFSKPIQEVLIEMTDGGVDYSFECIGNVKVMRAALEACHKGWGVSVVVGVAASGEEIATRPFQLVTGRTWKGTAFGGWKSVESVPKLVSEYMSKKIKVDEFVTHNLSFDEINKAFELMHSGKSIRTVVKI
  
Inhibitor
Name:
BDBM50465810
Synonyms:
CHEMBL4278220
Type:
Small organic molecule
Emp. Form.:
C15H10ClN7
Mol. Mass.:
323.74
SMILES:
Clc1cc(cnc1-c1ccc(cc1)-c1nnn[nH]1)-n1ccnc1
Structure:
Search PDB for entries with ligand similarity: