Reaction Details Report a problem with these data
Target
Alcohol dehydrogenase class-3
Ligand
BDBM50465805
Substrate
n/a
Meas. Tech.
ChEMBL_1788806 (CHEMBL4260540)
IC50
7.1±n/a nM
Citation
 Muthukaman, N; Deshmukh, S; Tondlekar, S; Tambe, M; Pisal, D; Sarode, N; Mhatre, S; Chakraborti, S; Shah, D; Bhosale, VM; Kulkarni, A; Mahat, MYA; Jadhav, SB; Gudi, GS; Khairatkar-Joshi, N; Gharat, LA Discovery of 5-(2-chloro-4'-(1H-imidazol-1-yl)-[1,1'-biphenyl]-4-yl)-1H-tetrazole as potent and orally efficacious S-nitrosoglutathione reductase (GSNOR) inhibitors for the potential treatment of COPD. Bioorg Med Chem Lett 28:3766-3773 (2018) [PubMed]  Article 
Target
Name:
Alcohol dehydrogenase class-3
Synonyms:
1.1.1.- | 1.1.1.1 | 1.1.1.284 | ADH-B2 | ADHX_MOUSE | Adh-2 | Adh2 | Adh5 | Alcohol dehydrogenase 2 | Alcohol dehydrogenase 5 | Alcohol dehydrogenase B2 | Alcohol dehydrogenase class-3 | Alcohol dehydrogenase class-III | FALDH | FDH | GSH-FDH | Glutathione-dependent formaldehyde dehydrogenase | S-(hydroxymethyl)glutathione dehydrogenase
Type:
PROTEIN
Mol. Mass.:
39550.36
Organism:
Mus musculus
Description:
ChEMBL_11830
Residue:
374
Sequence:
MANQVIRCKAAVAWEAGKPLSIEEIEVAPPKAHEVRIKILATAVCHTDAYTLSGADPEGCFPVILGHEGAGIVESVGEGVTKLKAGDTVIPLYIPQCGECKFCLNPKTNLCQKIRVTQGKGLMPDGTSRFTCKGKSVFHFMGTSTFSEYTVVADISVAKIDPSAPLDKVCLLGCGISTGYGAAVNTAKVEPGSTCAVFGLGGVGLAVIMGCKVAGASRIIGIDINKDKFAKAKEFGASECISPQDFSKSIQEVLVEMTDGGVDYSFECIGNVKVMRSALEAAHKGWGVSVVVGVAASGEEISTRPFQLVTGRTWKGTAFGGWKSVESVPKLVSEYMSKKIKVDEFVTGNLSFDQINQAFDLMHSGDSIRTVLKM
  
Inhibitor
Name:
BDBM50465805
Synonyms:
CHEMBL4290485
Type:
Small organic molecule
Emp. Form.:
C16H11ClN6
Mol. Mass.:
322.752
SMILES:
Clc1cc(ccc1-c1ccc(cc1)-n1ccnc1)-c1nnn[nH]1
Structure:
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