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Target
D(1A) dopamine receptor
Ligand
BDBM50465943
Substrate
n/a
Meas. Tech.
ChEMBL_1789226 (CHEMBL4260960)
Ki
56±n/a nM
Citation
 Davoren, JE; Nason, D; Coe, J; Dlugolenski, K; Helal, C; Harris, AR; LaChapelle, E; Liang, S; Liu, Y; O'Connor, R; Orozco, CC; Rai, BK; Salafia, M; Samas, B; Xu, W; Kozak, R; Gray, D Discovery and Lead Optimization of Atropisomer D1 Agonists with Reduced Desensitization. J Med Chem 61:11384-11397 (2018) [PubMed]  Article 
Target
Name:
D(1A) dopamine receptor
Synonyms:
DA D1 receptor | DOPAMINE D1 | DRD1 | DRD1_HUMAN | Dopamine D1 receptor | Dopamine D1 receptor (D1R) | Dopamine D1A
Type:
Enzyme
Mol. Mass.:
49303.43
Organism:
Homo sapiens (Human)
Description:
P21728
Residue:
446
Sequence:
MRTLNTSAMDGTGLVVERDFSVRILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSKVTNFFVISLAVSDLLVAVLVMPWKAVAEIAGFWPFGSFCNIWVAFDIMCSTASILNLCVISVDRYWAISSPFRYERKMTPKAAFILISVAWTLSVLISFIPVQLSWHKAKPTSPSDGNATSLAETIDNCDSSLSRTYAISSSVISFYIPVAIMIVTYTRIYRIAQKQIRRIAALERAAVHAKNCQTTTGNGKPVECSQPESSFKMSFKRETKVLKTLSVIMGVFVCCWLPFFILNCILPFCGSGETQPFCIDSNTFDVFVWFGWANSSLNPIIYAFNADFRKAFSTLLGCYRLCPATNNAIETVSINNNGAAMFSSHHEPRGSISKECNLVYLIPHAVGSSEDLKKEEAAGIARPLEKLSPALSVILDYDTDVSLEKIQPITQNGQHPT
  
Inhibitor
Name:
BDBM50465943
Synonyms:
CHEMBL4286110
Type:
Small organic molecule
Emp. Form.:
C23H16N2O3
Mol. Mass.:
368.3847
SMILES:
COc1ccc2cnccc2c1-c1ccc(Oc2nccc3occc23)cc1
Structure:
Search PDB for entries with ligand similarity: