Reaction Details Report a problem with these data
Target
Nuclear receptor ROR-beta
Ligand
BDBM50466998
Substrate
n/a
Meas. Tech.
ChEMBL_1794704 (CHEMBL4266821)
IC50
76±n/a nM
Citation
 Doebelin, C; Patouret, R; Garcia-Ordonez, RD; Chang, MR; Dharmarajan, V; Novick, S; Ciesla, A; Campbell, S; Solt, LA; Griffin, PR; Kamenecka, TM Identification of potent ROR? modulators: Scaffold variation. Bioorg Med Chem Lett 28:3210-3215 (2018) [PubMed]  Article 
Target
Name:
Nuclear receptor ROR-beta
Synonyms:
NR1F2 | Nuclear receptor RZR-beta | Nuclear receptor subfamily 1 group F member 2 | RORB | RORB_HUMAN | RZRB | Retinoid-related orphan receptor-beta
Type:
PROTEIN
Mol. Mass.:
53227.30
Organism:
Homo sapiens (Human)
Description:
ChEMBL_107979
Residue:
470
Sequence:
MCENQLKTKADATAQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQNNASYSCPRQRNCLIDRTNRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLYAEVQKHQQRLQEQRQQQSGEAEALARVYSSSISNGLSNLNNETSGTYANGHVIDLPKSEGYYNVDSGQPSPDQSGLDMTGIKQIKQEPIYDLTSVPNLFTYSSFNNGQLAPGITMTEIDRIAQNIIKSHLETCQYTMEELHQLAWQTHTYEEIKAYQSKSREALWQQCAIQITHAIQYVVEFAKRITGFMELCQNDQILLLKSGCLEVVLVRMCRAFNPLNNTVLFEGKYGGMQMFKALGSDDLVNEAFDFAKNLCSLQLTEEEIALFSSAVLISPDRAWLIEPRKVQKLQEKIYFALQHVIQKNHLDDETLAKLIAKIPTITAVCNLHGEKLQVFKQSHPEIVNTLFPPLYKELFNPDCATGCK
  
Inhibitor
Name:
BDBM50466998
Synonyms:
CHEMBL4291888
Type:
Small organic molecule
Emp. Form.:
C19H14F3NO2S
Mol. Mass.:
377.38
SMILES:
COc1ccccc1C(=O)c1sc(N)cc1-c1cccc(c1)C(F)(F)F
Structure:
Search PDB for entries with ligand similarity: