Reaction Details Report a problem with these data
Target
Neutrophil elastase
Ligand
BDBM50025849
Substrate
n/a
Meas. Tech.
ChEMBL_96636 (CHEMBL705708)
Ki
1800000±n/a nM
Citation
 Groutas, WC; Abrams, WR; Theodorakis, MC; Kasper, AM; Rude, SA; Badger, RC; Ocain, TD; Miller, KE; Moi, MK; Brubaker, MJ Amino acid derived latent isocyanates: irreversible inactivation of porcine pancreatic elastase and human leukocyte elastase. J Med Chem 28:204-9 (1985) [PubMed]  Article 
Target
Name:
Neutrophil elastase
Synonyms:
Bone marrow serine protease | Chymotrypsin | Coagulation factor X | ELA2 | ELANE | ELNE_HUMAN | Elastase | Elastase-2 | HLE | Human leukocyte elastase | Leukocyte elastase | Leukocyte elastase (HLE) | Medullasin | Neutrophil elastase | Neutrophil elastase (HNE) | Neutrophil elastase (NE) | PMN elastase | Thrombin | Trypsin
Type:
Enzyme
Mol. Mass.:
28532.38
Organism:
Homo sapiens (Human)
Description:
P08246
Residue:
267
Sequence:
MTLGRRLACLFLACVLPALLLGGTALASEIVGGRRARPHAWPFMVSLQLRGGHFCGATLIAPNFVMSAAHCVANVNVRAVRVVLGAHNLSRREPTRQVFAVQRIFENGYDPVNLLNDIVILQLNGSATINANVQVAQLPAQGRRLGNGVQCLAMGWGLLGRNRGIASVLQELNVTVVTSLCRRSNVCTLVRGRQAGVCFGDSGSPLVCNGLIHGIASFVRGGCASGLYPDAFAPVAQFVNWIDSIIQRSEDNPCPHPRDPDPASRTH
  
Inhibitor
Name:
BDBM50025849
Synonyms:
2-[(Imidazole-1-carbonyl)-amino]-3-methyl-butyric acid methyl ester | CHEMBL291635
Type:
Small organic molecule
Emp. Form.:
C10H15N3O3
Mol. Mass.:
225.2444
SMILES:
COC(=O)[C@@H](NC(=O)n1ccnc1)C(C)C
Structure:
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