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Target
Aldo-keto reductase family 1 member B1
Ligand
BDBM50025975
Substrate
n/a
Meas. Tech.
ChEMBL_31779 (CHEMBL643105)
IC50
7300±n/a nM
Citation
 Kador, PF; Kinoshita, JH; Sharpless, NE Aldose reductase inhibitors: a potential new class of agents for the pharmacological control of certain diabetic complications. J Med Chem 28:841-9 (1985) [PubMed]  Article 
Target
Name:
Aldo-keto reductase family 1 member B1
Synonyms:
AKR1B1 | ALDR1 | ALDR_HUMAN | ALR2 | AR | Aldo-keto reductase family 1 member B1 (AKR1B1) | Aldose Reductase (ALR2) | Aldose reductase | Aldose reductase (AR)
Type:
Protein
Mol. Mass.:
35855.50
Organism:
Homo sapiens (Human)
Description:
P15121. 4LAU; 2IKI; 4LB4; 2FZD; 2FZ8; 1US0
Residue:
316
Sequence:
MASRLLLNNGAKMPILGLGTWKSPPGQVTEAVKVAIDVGYRHIDCAHVYQNENEVGVAIQEKLREQVVKREELFIVSKLWCTYHEKGLVKGACQKTLSDLKLDYLDLYLIHWPTGFKPGKEFFPLDESGNVVPSDTNILDTWAAMEELVDEGLVKAIGISNFNHLQVEMILNKPGLKYKPAVNQIECHPYLTQEKLIQYCQSKGIVVTAYSPLGSPDRPWAKPEDPSLLEDPRIKAIAAKHNKTTAQVLIRFPMQRNLVVIPKSVTPERIAENFKVFDFELSSQDMTTLLSYNRNWRVCALLSCTSHKDYPFHEEF
  
Inhibitor
Name:
BDBM50025975
Synonyms:
3-Hydroxy-11-oxo-11H-pyrido[2,1-b]quinazoline-8-carboxylic acid | CHEMBL168614
Type:
Small organic molecule
Emp. Form.:
C13H8N2O4
Mol. Mass.:
256.2136
SMILES:
OC(=O)c1ccc2nc3cc(O)ccc3c(=O)n2c1
Structure:
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