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Target
Aldo-keto reductase family 1 member B1
Ligand
BDBM50025980
Substrate
n/a
Meas. Tech.
ChEBML_32096
IC50
2500±n/a nM
Citation
 Kador, PF; Kinoshita, JH; Sharpless, NE Aldose reductase inhibitors: a potential new class of agents for the pharmacological control of certain diabetic complications. J Med Chem 28:841-9 (1985) [PubMed]  Article 
Target
Name:
Aldo-keto reductase family 1 member B1
Synonyms:
ALDR_RAT | Akr1b1 | Akr1b4 | Aldose reductase | Aldr1
Type:
PROTEIN
Mol. Mass.:
35797.87
Organism:
Rattus norvegicus
Description:
ChEMBL_1512484
Residue:
316
Sequence:
MASHLELNNGTKMPTLGLGTWKSPPGQVTEAVKVAIDMGYRHIDCAQVYQNEKEVGVALQEKLKEQVVKRQDLFIVSKLWCTFHDQSMVKGACQKTLSDLQLDYLDLYLIHWPTGFKPGPDYFPLDASGNVIPSDTDFVDTWTAMEQLVDEGLVKAIGVSNFNPLQIERILNKPGLKYKPAVNQIECHPYLTQEKLIEYCHCKGIVVTAYSPLGSPDRPWAKPEDPSLLEDPRIKEIAAKYNKTTAQVLIRFPIQRNLVVIPKSVTPARIAENFKVFDFELSNEDMATLLSYNRNWRVCALMSCAKHKDYPFHAEV
  
Inhibitor
Name:
BDBM50025980
Synonyms:
7-Hydroxy-4-oxo-4H-chromene-2-carboxylic acid benzyl ester | CHEMBL166825
Type:
Small organic molecule
Emp. Form.:
C17H12O5
Mol. Mass.:
296.2742
SMILES:
Oc1ccc2c(c1)oc(cc2=O)C(=O)OCc1ccccc1
Structure:
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