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Target
Mitogen-activated protein kinase 13
Ligand
BDBM50473632
Substrate
n/a
Meas. Tech.
ChEMBL_124318 (CHEMBL732626)
IC50
5.0±n/a nM
Citation
 McKenna, JM; Halley, F; Souness, JE; McLay, IM; Pickett, SD; Collis, AJ; Page, K; Ahmed, I An algorithm-directed two-component library synthesized via solid-phase methodology yielding potent and orally bioavailable p38 MAP kinase inhibitors. J Med Chem 45:2173-84 (2002) [PubMed]  Article 
Target
Name:
Mitogen-activated protein kinase 13
Synonyms:
MAP kinase 13 | MAP kinase p38 delta | MAPK 13 | MK13_MOUSE | Mapk13 | Mitogen-activated protein kinase 13 | Mitogen-activated protein kinase p38 delta | Serk4 | Stress-activated protein kinase 4
Type:
PROTEIN
Mol. Mass.:
42081.17
Organism:
Mus musculus
Description:
ChEMBL_105000
Residue:
366
Sequence:
MSLTRKRGFYKQDINKTAWELPKTYLAPAHVGSGAYGAVCSAIDKRTGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMHHENVIGLLDVFTPASSLRSFHDFYLVMPFMQTDLQKIMGMEFSEDKVQYLVYQMLKGLKYIHSAGIVHRDLKPGNLAVNEDCELKILDFGLARHTDTEMTGYVVTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGAEFVQKLKDKAAKSYIQSLPQSPKKDFTQLFPRASPQAADLLDKMLELDVDKRLTAAQALAHPFFEPFRDPEEETEAQQPFDDALEHEKLSVDEWKQHIYKEISNFSPIARKDSRRRSGMKLQ
  
Inhibitor
Name:
BDBM50473632
Synonyms:
CHEMBL71425 | RPR-239457
Type:
Small organic molecule
Emp. Form.:
C26H29FN6O3
Mol. Mass.:
492.5453
SMILES:
C[C@@]1(CO[C@@H](OC1)c1nc(c([nH]1)-c1ccnc(NCC2CC2)n1)-c1ccc(F)cc1)C(=O)NC1CC1 |wU:4.7,1.0,wD:1.34,(21.05,-9.06,;20.3,-10.39,;19.53,-9.06,;17.99,-9.06,;17.23,-10.39,;17.99,-11.72,;19.52,-11.72,;15.69,-10.39,;14.76,-11.63,;13.3,-11.15,;13.31,-9.61,;14.79,-9.13,;11.98,-8.82,;11.98,-7.28,;10.64,-6.51,;9.31,-7.28,;9.31,-8.82,;7.96,-9.59,;6.62,-8.82,;5.29,-9.59,;4.52,-10.93,;3.75,-9.59,;10.64,-9.59,;12.05,-12.05,;10.65,-11.41,;9.4,-12.31,;9.55,-13.85,;8.21,-14.61,;10.97,-14.48,;12.21,-13.57,;21.05,-11.72,;20.28,-13.05,;22.59,-11.72,;23.37,-13.08,;23.37,-14.62,;24.7,-13.85,)|
Structure:
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