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TargetEndothelial PAS domain-containing protein 1/Hypoxia-inducible factor 1-alpha
LigandBDBM50481802
Substrate/Competitorn/a
Meas. Tech.ChEMBL_621709
IC50>30000±n/a nM
Citation Liu, YLiu, RMao, SCMorgan, JBJekabsons, MBZhou, YDNagle, DG Molecular-targeted antitumor agents. 19. Furospongolide from a marine Lendenfeldia sp. sponge inhibits hypoxia-inducible factor-1 activation in breast tumor cells. J Nat Prod71:1854-60 (2008) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Endothelial PAS domain-containing protein 1/Hypoxia-inducible factor 1-alpha
Name:Endothelial PAS domain-containing protein 1/Hypoxia-inducible factor 1-alpha
Synonyms:Hypoxia inducible factors; HIF-1-alpha, HIF-2-alpha
Type:n/a
Mol. Mass.:n/a
Description:ASSAY_ID of ChEMBL is 799337
Components:This complex has 2 components.
Component 1
Name:Hypoxia-inducible factor 1-alpha
Synonyms:HIF-1-alpha | HIF-1-alpha, HIF-2-alpha | Hypoxia inducible factors | Hypoxia-inducible factor 1 alpha | Hypoxia-inducible factor 1-alpha | von Hippel-Lindau disease tumor suppressor/Elongin-C/Elongin-B/HIF1A
Type:Protein
Mol. Mass.:92647.24
Organism:Homo sapiens (Human)
Description:Q16665
Residue:826
Sequence:
MEGAGGANDKKKISSERRKEKSRDAARSRRSKESEVFYELAHQLPLPHNVSSHLDKASVM
RLTISYLRVRKLLDAGDLDIEDDMKAQMNCFYLKALDGFVMVLTDDGDMIYISDNVNKYM
GLTQFELTGHSVFDFTHPCDHEEMREMLTHRNGLVKKGKEQNTQRSFFLRMKCTLTSRGR
TMNIKSATWKVLHCTGHIHVYDTNSNQPQCGYKKPPMTCLVLICEPIPHPSNIEIPLDSK
TFLSRHSLDMKFSYCDERITELMGYEPEELLGRSIYEYYHALDSDHLTKTHHDMFTKGQV
TTGQYRMLAKRGGYVWVETQATVIYNTKNSQPQCIVCVNYVVSGIIQHDLIFSLQQTECV
LKPVESSDMKMTQLFTKVESEDTSSLFDKLKKEPDALTLLAPAAGDTIISLDFGSNDTET
DDQQLEEVPLYNDVMLPSPNEKLQNINLAMSPLPTAETPKPLRSSADPALNQEVALKLEP
NPESLELSFTMPQIQDQTPSPSDGSTRQSSPEPNSPSEYCFYVDSDMVNEFKLELVEKLF
AEDTEAKNPFSTQDTDLDLEMLAPYIPMDDDFQLRSFDQLSPLESSSASPESASPQSTVT
VFQQTQIQEPTANATTTTATTDELKTVTKDRMEDIKILIASPSPTHIHKETTSATSSPYR
DTQSRTASPNRAGKGVIEQTEKSHPRSPNVLSVALSQRTTVPEEELNPKILALQNAQRKR
KMEHDGSLFQAVGIGTLLQQPDDHAATTSLSWKRVKGCKSSEQNGMEQKTIILIPSDLAC
RLLGQSMDESGLPQLTSYDCEVNAPIQGSRNLLQGEELLRALDQVN
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Component 2
Name:Endothelial PAS domain-containing protein 1
Synonyms:endothelial PAS domain-containing protein 1
Type:PROTEIN
Mol. Mass.:96453.58
Organism:Homo sapiens (Human)
Description:ChEMBL_1506501
Residue:870
Sequence:
MTADKEKKRSSSERRKEKSRDAARCRRSKETEVFYELAHELPLPHSVSSHLDKASIMRLA
ISFLRTHKLLSSVCSENESEAEADQQMDNLYLKALEGFIAVVTQDGDMIFLSENISKFMG
LTQVELTGHSIFDFTHPCDHEEIRENLSLKNGSGFGKKSKDMSTERDFFMRMKCTVTNRG
RTVNLKSATWKVLHCTGQVKVYNNCPPHNSLCGYKEPLLSCLIIMCEPIQHPSHMDIPLD
SKTFLSRHSMDMKFTYCDDRITELIGYHPEELLGRSAYEFYHALDSENMTKSHQNLCTKG
QVVSGQYRMLAKHGGYVWLETQGTVIYNPRNLQPQCIMCVNYVLSEIEKNDVVFSMDQTE
SLFKPHLMAMNSIFDSSGKGAVSEKSNFLFTKLKEEPEELAQLAPTPGDAIISLDFGNQN
FEESSAYGKAILPPSQPWATELRSHSTQSEAGSLPAFTVPQAAAPGSTTPSATSSSSSCS
TPNSPEDYYTSLDNDLKIEVIEKLFAMDTEAKDQCSTQTDFNELDLETLAPYIPMDGEDF
QLSPICPEERLLAENPQSTPQHCFSAMTNIFQPLAPVAPHSPFLLDKFQQQLESKKTEPE
HRPMSSIFFDAGSKASLPPCCGQASTPLSSMGGRSNTQWPPDPPLHFGPTKWAVGDQRTE
FLGAAPLGPPVSPPHVSTFKTRSAKGFGARGPDVLSPAMVALSNKLKLKRQLEYEEQAFQ
DLSGGDPPGGSTSHLMWKRMKNLRGGSCPLMPDKPLSANVPNDKFTQNPMRGLGHPLRHL
PLPQPPSAISPGENSKSRFPPQCYATQYQDYSLSSAHKVSGMASRLLGPSFESYLLPELT
RYDCEVNVPVLGSSTLLQGGDLLRALDQAT
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BDBM50481802
NameBDBM50481802
Synonyms:CHEBI:67727 | FUROSPONGOLIDE | Furospongolide
TypeSmall organic molecule
Emp. Form.C21H28O3
Mol. Mass.328.4452
SMILESC\C(CCCC1=CC(=O)OC1)=C/CC\C(C)=C\CCc1ccoc1 |t:5|
Structure
n/a