| Reaction Details |
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 | Report a problem with these data |
| Target | Endothelial PAS domain-containing protein 1/Hypoxia-inducible factor 1-alpha |
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| Ligand | BDBM50481802 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_621707 |
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| IC50 | >30000±n/a nM |
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| Citation |  Liu, Y; Liu, R; Mao, SC; Morgan, JB; Jekabsons, MB; Zhou, YD; Nagle, DG Molecular-targeted antitumor agents. 19. Furospongolide from a marine Lendenfeldia sp. sponge inhibits hypoxia-inducible factor-1 activation in breast tumor cells. J Nat Prod71:1854-60 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Endothelial PAS domain-containing protein 1/Hypoxia-inducible factor 1-alpha |
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| Name: | Endothelial PAS domain-containing protein 1/Hypoxia-inducible factor 1-alpha |
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| Synonyms: | Hypoxia inducible factors; HIF-1-alpha, HIF-2-alpha |
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| Type: | n/a |
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| Mol. Mass.: | n/a |
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| Description: | ASSAY_ID of ChEMBL is 799337 |
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| Components: | This complex has 2 components. |
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| Component 1 |
| Name: | Hypoxia-inducible factor 1-alpha |
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| Synonyms: | HIF-1-alpha | HIF-1-alpha, HIF-2-alpha | Hypoxia inducible factors | Hypoxia-inducible factor 1 alpha | Hypoxia-inducible factor 1-alpha | von Hippel-Lindau disease tumor suppressor/Elongin-C/Elongin-B/HIF1A |
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| Type: | Protein |
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| Mol. Mass.: | 92647.24 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q16665 |
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| Residue: | 826 |
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| Sequence: | MEGAGGANDKKKISSERRKEKSRDAARSRRSKESEVFYELAHQLPLPHNVSSHLDKASVM
RLTISYLRVRKLLDAGDLDIEDDMKAQMNCFYLKALDGFVMVLTDDGDMIYISDNVNKYM
GLTQFELTGHSVFDFTHPCDHEEMREMLTHRNGLVKKGKEQNTQRSFFLRMKCTLTSRGR
TMNIKSATWKVLHCTGHIHVYDTNSNQPQCGYKKPPMTCLVLICEPIPHPSNIEIPLDSK
TFLSRHSLDMKFSYCDERITELMGYEPEELLGRSIYEYYHALDSDHLTKTHHDMFTKGQV
TTGQYRMLAKRGGYVWVETQATVIYNTKNSQPQCIVCVNYVVSGIIQHDLIFSLQQTECV
LKPVESSDMKMTQLFTKVESEDTSSLFDKLKKEPDALTLLAPAAGDTIISLDFGSNDTET
DDQQLEEVPLYNDVMLPSPNEKLQNINLAMSPLPTAETPKPLRSSADPALNQEVALKLEP
NPESLELSFTMPQIQDQTPSPSDGSTRQSSPEPNSPSEYCFYVDSDMVNEFKLELVEKLF
AEDTEAKNPFSTQDTDLDLEMLAPYIPMDDDFQLRSFDQLSPLESSSASPESASPQSTVT
VFQQTQIQEPTANATTTTATTDELKTVTKDRMEDIKILIASPSPTHIHKETTSATSSPYR
DTQSRTASPNRAGKGVIEQTEKSHPRSPNVLSVALSQRTTVPEEELNPKILALQNAQRKR
KMEHDGSLFQAVGIGTLLQQPDDHAATTSLSWKRVKGCKSSEQNGMEQKTIILIPSDLAC
RLLGQSMDESGLPQLTSYDCEVNAPIQGSRNLLQGEELLRALDQVN
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| Component 2 |
| Name: | Endothelial PAS domain-containing protein 1 |
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| Synonyms: | endothelial PAS domain-containing protein 1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 96453.58 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1506501 |
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| Residue: | 870 |
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| Sequence: | MTADKEKKRSSSERRKEKSRDAARCRRSKETEVFYELAHELPLPHSVSSHLDKASIMRLA
ISFLRTHKLLSSVCSENESEAEADQQMDNLYLKALEGFIAVVTQDGDMIFLSENISKFMG
LTQVELTGHSIFDFTHPCDHEEIRENLSLKNGSGFGKKSKDMSTERDFFMRMKCTVTNRG
RTVNLKSATWKVLHCTGQVKVYNNCPPHNSLCGYKEPLLSCLIIMCEPIQHPSHMDIPLD
SKTFLSRHSMDMKFTYCDDRITELIGYHPEELLGRSAYEFYHALDSENMTKSHQNLCTKG
QVVSGQYRMLAKHGGYVWLETQGTVIYNPRNLQPQCIMCVNYVLSEIEKNDVVFSMDQTE
SLFKPHLMAMNSIFDSSGKGAVSEKSNFLFTKLKEEPEELAQLAPTPGDAIISLDFGNQN
FEESSAYGKAILPPSQPWATELRSHSTQSEAGSLPAFTVPQAAAPGSTTPSATSSSSSCS
TPNSPEDYYTSLDNDLKIEVIEKLFAMDTEAKDQCSTQTDFNELDLETLAPYIPMDGEDF
QLSPICPEERLLAENPQSTPQHCFSAMTNIFQPLAPVAPHSPFLLDKFQQQLESKKTEPE
HRPMSSIFFDAGSKASLPPCCGQASTPLSSMGGRSNTQWPPDPPLHFGPTKWAVGDQRTE
FLGAAPLGPPVSPPHVSTFKTRSAKGFGARGPDVLSPAMVALSNKLKLKRQLEYEEQAFQ
DLSGGDPPGGSTSHLMWKRMKNLRGGSCPLMPDKPLSANVPNDKFTQNPMRGLGHPLRHL
PLPQPPSAISPGENSKSRFPPQCYATQYQDYSLSSAHKVSGMASRLLGPSFESYLLPELT
RYDCEVNVPVLGSSTLLQGGDLLRALDQAT
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| BDBM50481802 |
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| Name | BDBM50481802 |
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| Synonyms: | CHEBI:67727 | FUROSPONGOLIDE | Furospongolide |
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| Type | Small organic molecule |
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| Emp. Form. | C21H28O3 |
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| Mol. Mass. | 328.4452 |
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| SMILES | C\C(CCCC1=CC(=O)OC1)=C/CC\C(C)=C\CCc1ccoc1 |t:5| |
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| Structure |  |
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| n/a |
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