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Target
Penicillin-binding protein 2B
Ligand
BDBM50482777
Substrate
n/a
Meas. Tech.
ChEMBL_672083 (CHEMBL1267464)
IC50
>70200±n/a nM
Citation
 Kosowska-Shick, K; McGhee, PL; Appelbaum, PC Affinity of ceftaroline and other beta-lactams for penicillin-binding proteins from Staphylococcus aureus and Streptococcus pneumoniae. Antimicrob Agents Chemother 54:1670-7 (2010) [PubMed]  Article 
Target
Name:
Penicillin-binding protein 2B
Synonyms:
PBP2_STRPN | Penicillin-binding protein 2B | pbp2b | pbp2b | penA
Type:
PROTEIN
Mol. Mass.:
73859.38
Organism:
Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
Description:
ChEMBL_103544
Residue:
680
Sequence:
MRKFNSHSIPIRLNLLFSIVILLFMTIIGRLLYMQVLNKDFYEKKLASASQTKITSSSARGEIYDASGKPLVENTLKQVVSFTRSNKMTATDLKETAKKLLTYVSISSPNLTERQLADYYLADPEIYKKIVEALPSEKRLDSDGNRLSESELYNNAVDSVQTSQLNYTEDEKKEIYLFSQLNAVGNFATGTIATDPLNDSQVAVIASISKEMPGISISTSWDRKVLETSLSSIVGSVSSEKAGLPAEEAEAYLKKGYSLNDRVGTSYLEKQYEETLQGKRSVKEIHLDKYGNMESVDTIEEGSKGNNIKLTIDLAFQDSVDALLKSYFNSELENGGAKYSEGVYAVALNPKTGAVLSMSGIKHDLKTGELTPDSLGTVTNVFVPGSVVKAATISSGWENGVLSGNQTLTDQSIVFQGSAPINSWYTQAYGSFPITAVQALEYSSNTYMVQTALGLMGQTYQPNMFVGTSNLESAMEKLRSTFGEYGLGTATGIDLPDESTGFVPKEYSFANYITNAFGQFDNYTPMQLAQYVATIANNGVRVAPRIVEGIYGNNDKGGLGDLIQQLQPTEMNKVNISDSDMSILHQGFYQVAHGTSGLTTGRAFSNGALVSISGKTGTAESYVADGQQATNTNAVAYAPSDNPQIAVAVVFPHNTNLTNGVGPSIARDIINLYQKYHPMN
  
Inhibitor
Name:
BDBM50482777
Synonyms:
CHEBI:204928 | Cefotaxime
Type:
Small organic molecule
Emp. Form.:
C16H17N5O7S2
Mol. Mass.:
455.465
SMILES:
[H][C@]12SCC(COC(C)=O)=C(N1C(=O)[C@H]2NC(=O)C(=N/OC)\c1csc(N)n1)C(O)=O |c:9|
Structure:
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