Target
Neutrophil elastase
Ligand
BDBM50029693
Substrate
n/a
Meas. Tech.
ChEMBL_64004 (CHEMBL672345)
Ki
0.22±n/a nM
Citation
 Hlasta, DJAckerman, JHCourt, JJFarrell, RPJohnson, JAKofron, JLRobinson, DTTalomie, TGDunlap, RPFranke, CA A novel class of cyclic beta-dicarbonyl leaving groups and their use in the design of benzisothiazolone human leukocyte elastase inhibitors. J Med Chem 38:4687-92 (1995) [PubMed]  Article 
Target
Name:
Neutrophil elastase
Synonyms:
Bone marrow serine protease | Chymotrypsin | Coagulation factor X | ELA2 | ELANE | ELNE_HUMAN | Elastase | Elastase-2 | HLE | Human leukocyte elastase | Leukocyte elastase | Leukocyte elastase (HLE) | Medullasin | Neutrophil elastase | Neutrophil elastase (HNE) | Neutrophil elastase (NE) | PMN elastase | Thrombin | Trypsin
Type:
Enzyme
Mol. Mass.:
28532.38
Organism:
Homo sapiens (Human)
Description:
P08246
Residue:
267
Sequence:
MTLGRRLACLFLACVLPALLLGGTALASEIVGGRRARPHAWPFMVSLQLRGGHFCGATLIAPNFVMSAAHCVANVNVRAVRVVLGAHNLSRREPTRQVFAVQRIFENGYDPVNLLNDIVILQLNGSATINANVQVAQLPAQGRRLGNGVQCLAMGWGLLGRNRGIASVLQELNVTVVTSLCRRSNVCTLVRGRQAGVCFGDSGSPLVCNGLIHGIASFVRGGCASGLYPDAFAPVAQFVNWIDSIIQRSEDNPCPHPRDPDPASRTH
  
Inhibitor
Name:
BDBM50029693
Synonyms:
4-Isopropyl-6-methoxy-1,1-dioxo-2-(2-oxo-2H-thiochromen-4-yloxymethyl)-1,2-dihydro-1lambda*6*-benzo[d]isothiazol-3-one | CHEMBL341905
Type:
Small organic molecule
Emp. Form.:
C21H19NO6S2
Mol. Mass.:
445.509
SMILES:
COc1cc2c(C(=O)N(COc3cc(=O)sc4ccccc34)S2(=O)=O)c(c1)C(C)C
Structure:
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