Reaction Details Report a problem with these data
Target
Uridine phosphorylase 1
Ligand
BDBM50031006
Substrate
n/a
Meas. Tech.
ChEMBL_212951 (CHEMBL873996)
IC50
100±n/a nM
Citation
 Orr, GF; Musso, DL; Boswell, GE; Kelley, JL; Joyner, SS; Davis, ST; Baccanari, DP Inhibition of uridine phosphorylase: synthesis and structure-activity relationships of aryl-substituted 5-benzyluracils and 1-[(2-hydroxyethoxy)methyl]-5-benzyluracils. J Med Chem 38:3850-6 (1995) [PubMed]  Article 
Target
Name:
Uridine phosphorylase 1
Synonyms:
UPP1_MOUSE | Up | Upp | Upp1
Type:
PROTEIN
Mol. Mass.:
34086.29
Organism:
Mus musculus
Description:
ChEMBL_212951
Residue:
311
Sequence:
MAATGTEAKDLENHHNDCFIQLSNPNIAAMKEDVLYHFNLSTSTHDFPAMFGDVKFVCVGGSSSRMNTFIKYVAAELGLDHPGKEYPNICAGTDRYAMYKAGPVLSVSHGMGIPSIGIMLHELIKMLYHARCSNITIIRIGTSGGIGLEPGSVVITQQAVNECFKPEFEQIVLGKRVIRNTNLDAQLVQELVQCSSDLNEFPMVVGNTMCTLDFYEGQGRLDGALCSYTEKDKQSYLRAAHAAGVRNIEMESSVFATMCSACGLKAAVVCVTLLDRLQGDQINTPHDVLVEYQQRPQRLVGHFIKKSLGRA
  
Inhibitor
Name:
BDBM50031006
Synonyms:
5-(3-Ethoxy-benzyl)-1-(2-hydroxy-ethoxymethyl)-1H-pyrimidine-2,4-dione | CHEMBL127250
Type:
Small organic molecule
Emp. Form.:
C16H20N2O5
Mol. Mass.:
320.3404
SMILES:
CCOc1cccc(Cc2cn(COCCO)c(=O)[nH]c2=O)c1
Structure:
Search PDB for entries with ligand similarity: