Target
Renin
Ligand
BDBM50291951
Substrate
n/a
Meas. Tech.
ChEMBL_196279 (CHEMBL806633)
KOFF
0.00133 s-1
KON
5.43 M-1s-1
Citation
 Morelock, MMPargellis, CAGraham, ETLamarre, DJung, G Time-resolved ligand exchange reactions: kinetic models for competitive inhibitors with recombinant human renin. J Med Chem 38:1751-61 (1995) [PubMed]  Article 
Target
Name:
Renin
Synonyms:
Angiotensinogenase | REN | RENI_HUMAN
Type:
Enzyme
Mol. Mass.:
45058.99
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
406
Sequence:
MDGWRRMPRWGLLLLLWGSCTFGLPTDTTTFKRIFLKRMPSIRESLKERGVDMARLGPEWSQPMKRLTLGNTTSSVILTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRLYTACVYHKLFDASDSSSYKHNGTELTLRYSTGTVSGFLSQDIITVGGITVTQMFGEVTEMPALPFMLAEFDGVVGMGFIEQAIGRVTPIFDNIISQGVLKEDVFSFYYNRDSENSQSLGGQIVLGGSDPQHYEGNFHYINLIKTGVWQIQMKGVSVGSSTLLCEDGCLALVDTGASYISGSTSSIEKLMEALGAKKRLFDYVVKCNEGPTLPDISFHLGGKEYTLTSADYVFQESYSSKKLCTLAIHAMDIPPPTGPTWALGATFIRKFYTEFDRRNNRIGFALAR
  
Inhibitor
Name:
BDBM50291951
Synonyms:
(R)-2-(2-Amino-thiazol-4-ylmethyl)-N*1*-((1S,2R,3S)-1-cyclohexylmethyl-2,3-dihydroxy-5-methyl-hexyl)-N*4*-[(methyl-{2-[methyl-(morpholine-4-carbonyl)-amino]-ethyl}-carbamoyl)-methyl]-N*4*-((S)-1-phenyl-ethyl)-succinamide | CHEMBL430781
Type:
Small organic molecule
Emp. Form.:
C41H65N7O7S
Mol. Mass.:
800.063
SMILES:
CC(C)C[C@H](O)[C@H](O)[C@H](CC1CCCCC1)NC(=O)[C@@H](CC(=O)N(CC(=O)N(C)CCN(C)C(=O)N1CCOCC1)[C@@H](C)c1ccccc1)Cc1csc(N)n1
Structure:
Search PDB for entries with ligand similarity: