Reaction Details Report a problem with these data
Target
Gag-Pol polyprotein [489-587]
Ligand
BDBM50036255
Substrate
n/a
Meas. Tech.
ChEMBL_157540 (CHEMBL764925)
Ki
125±n/a nM
Citation
 Vazquez, ML; Bryant, ML; Clare, M; DeCrescenzo, GA; Doherty, EM; Freskos, JN; Getman, DP; Houseman, KA; Julien, JA; Kocan, GP Inhibitors of HIV-1 protease containing the novel and potent (R)-(hydroxyethyl)sulfonamide isostere. J Med Chem 38:581-4 (1995) [PubMed]  Article 
Target
Name:
Gag-Pol polyprotein [489-587]
Synonyms:
Human immunodeficiency virus type 1 protease | POL_HV1H2 | Pol polyprotein | gag-pol
Type:
Enzyme Subunit
Mol. Mass.:
10781.16
Organism:
Human immunodeficiency virus type 1
Description:
P04585[489-587]
Residue:
99
Sequence:
PQVTLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMSLPGRWKPKMIGGIGGFIKVRQYDQILIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF
  
Inhibitor
Name:
BDBM50036255
Synonyms:
CHEMBL154197 | [(1S,2R)-3-(Benzenesulfonyl-benzyl-amino)-1-benzyl-2-hydroxy-propyl]-carbamic acid benzyl ester
Type:
Small organic molecule
Emp. Form.:
C31H32N2O5S
Mol. Mass.:
544.661
SMILES:
O[C@H](CN(Cc1ccccc1)S(=O)(=O)c1ccccc1)[C@H](Cc1ccccc1)NC(=O)OCc1ccccc1
Structure:
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