Target
Gag-Pol polyprotein [489-587]
Ligand
BDBM50036264
Substrate
n/a
Meas. Tech.
ChEMBL_157543 (CHEMBL764927)
Ki
227±n/a nM
Citation
 Vazquez, MLBryant, MLClare, MDeCrescenzo, GADoherty, EMFreskos, JNGetman, DPHouseman, KAJulien, JAKocan, GP Inhibitors of HIV-1 protease containing the novel and potent (R)-(hydroxyethyl)sulfonamide isostere. J Med Chem 38:581-4 (1995) [PubMed]  Article 
Target
Name:
Gag-Pol polyprotein [489-587]
Synonyms:
Human immunodeficiency virus type 1 protease | POL_HV1H2 | Pol polyprotein | gag-pol
Type:
Enzyme Subunit
Mol. Mass.:
10781.16
Organism:
Human immunodeficiency virus type 1
Description:
P04585[489-587]
Residue:
99
Sequence:
PQVTLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMSLPGRWKPKMIGGIGGFIKVRQYDQILIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF
  
Inhibitor
Name:
BDBM50036264
Synonyms:
CHEMBL154600 | {(1S,2R)-1-Benzyl-3-[(2-chloro-benzenesulfonyl)-(3-methyl-butyl)-amino]-2-hydroxy-propyl}-carbamic acid benzyl ester
Type:
Small organic molecule
Emp. Form.:
C29H35ClN2O5S
Mol. Mass.:
559.117
SMILES:
CC(C)CCN(C[C@@H](O)[C@H](Cc1ccccc1)NC(=O)OCc1ccccc1)S(=O)(=O)c1ccccc1Cl
Structure:
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