Reaction Details Report a problem with these data
Target
Neutrophil elastase
Ligand
BDBM50291921
Substrate
n/a
Meas. Tech.
ChEMBL_64660 (CHEMBL674812)
KON
1.3 M-1s-1
Citation
 Alpegiani, M; Bissolino, P; Corigli, R; Del Nero, S; Perrone, E; Rizzo, V; Sacchi, N; Cassinelli, G; Franceschi, G; Baici, A Cephem sulfones as inactivators of human leukocyte elastase. 5. 7 alpha-Methoxy- and 7 alpha-chloro-1,1-dioxocephem 4-ketones. J Med Chem 37:4003-19 (1994) [PubMed]  Article 
Target
Name:
Neutrophil elastase
Synonyms:
Bone marrow serine protease | Chymotrypsin | Coagulation factor X | ELA2 | ELANE | ELNE_HUMAN | Elastase | Elastase-2 | HLE | Human leukocyte elastase | Leukocyte elastase | Leukocyte elastase (HLE) | Medullasin | Neutrophil elastase | Neutrophil elastase (HNE) | Neutrophil elastase (NE) | PMN elastase | Thrombin | Trypsin
Type:
Enzyme
Mol. Mass.:
28532.38
Organism:
Homo sapiens (Human)
Description:
P08246
Residue:
267
Sequence:
MTLGRRLACLFLACVLPALLLGGTALASEIVGGRRARPHAWPFMVSLQLRGGHFCGATLIAPNFVMSAAHCVANVNVRAVRVVLGAHNLSRREPTRQVFAVQRIFENGYDPVNLLNDIVILQLNGSATINANVQVAQLPAQGRRLGNGVQCLAMGWGLLGRNRGIASVLQELNVTVVTSLCRRSNVCTLVRGRQAGVCFGDSGSPLVCNGLIHGIASFVRGGCASGLYPDAFAPVAQFVNWIDSIIQRSEDNPCPHPRDPDPASRTH
  
Inhibitor
Name:
BDBM50291921
Synonyms:
(S)-3-Acetoxymethyl-7-chloro-5,5,8-trioxo-5lambda*6*-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid methyl ester | CHEMBL339126
Type:
Small organic molecule
Emp. Form.:
C11H12ClNO7S
Mol. Mass.:
337.733
SMILES:
COC(=O)C1=C(COC(C)=O)CS(=O)(=O)C2[C@@H](Cl)C(=O)N12 |c:4|
Structure:
Search PDB for entries with ligand similarity: