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Target
Carbonic anhydrase 2
Ligand
BDBM50038962
Substrate
n/a
Meas. Tech.
ChEMBL_45051 (CHEMBL658049)
Kd
2.1±n/a nM
Citation
 Jain, A; Whitesides, GM; Alexander, RS; Christianson, DW Identification of two hydrophobic patches in the active-site cavity of human carbonic anhydrase II by solution-phase and solid-state studies and their use in the development of tight-binding inhibitors. J Med Chem 37:2100-5 (1994) [PubMed]  Article 
Target
Name:
Carbonic anhydrase 2
Synonyms:
CA-II | CA2 | CAC | CAH2_HUMAN | Carbonate dehydratase II | Carbonic anhydrase 2 (CA II) | Carbonic anhydrase 2 (CA-II) | Carbonic anhydrase 2 (Recombinant CA II) | Carbonic anhydrase C | Carbonic anhydrase II (CA II) | Carbonic anhydrase II (CA-II) | Carbonic anhydrase II (CAII) | Carbonic anhydrase II (hCA II) | Carbonic anhydrase isoenzyme II (hCA II)
Type:
Enzyme
Mol. Mass.:
29250.71
Organism:
Homo sapiens (Human)
Description:
P00918
Residue:
260
Sequence:
MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK
  
Inhibitor
Name:
BDBM50038962
Synonyms:
CHEMBL302105 | N-Adamantan-1-ylmethyl-4-sulfamoyl-benzamide
Type:
Small organic molecule
Emp. Form.:
C18H24N2O3S
Mol. Mass.:
348.46
SMILES:
NS(=O)(=O)c1ccc(cc1)C(=O)NCC12CC3CC(CC(C3)C1)C2 |TLB:17:18:22:16.15.21,21:20:23:16.15.17,21:16:23:20.22.19,THB:17:16:22:18.23.19,19:20:15:18.23.17,19:18:15:20.22.21|
Structure:
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