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Target
Vesicular acetylcholine transporter
Ligand
BDBM50039612
Substrate
n/a
Meas. Tech.
ChEMBL_213554 (CHEMBL816914)
Ki
24.25±n/a nM
Citation
 Efange, SM; Khare, AB; Foulon, C; Akella, SK; Parsons, SM Spirovesamicols: conformationally restricted analogs of 2-(4-phenylpiperidino)cyclohexanol (vesamicol, AH5183) as potential modulators of presynaptic cholinergic function. J Med Chem 37:2574-82 (1994) [PubMed]  Article 
Target
Name:
Vesicular acetylcholine transporter
Synonyms:
TorVAChT | VACHT_TETCF | VAChT
Type:
PROTEIN
Mol. Mass.:
56111.93
Organism:
Torpedo californica
Description:
ChEMBL_1503355
Residue:
515
Sequence:
MGVTMAVGLAKAAMGKISSAIGERSKRISGAMNEPRRKRKILLVIVCIAMLLDNMLYMVIVPIIPNYLETIRTYKLVYITTPSNGTNGSLLNSTQRAVLERNPNANEDIQIGVLFASKAILQLLSNPFTGTFIDRVGYDIPLLIGLTIMFFSTITFAFGESYAVLFAARSLQGLGSAFADTSGIAMIADKYTEESERTQALGIALAFISFGSLVAPPFGGVLYQFAGKWVPFLVLSFVCLLDGILLLMVVTPFASRTRENMLQGTPIYKLMIDPYIAVVAGALTTCNIPLAFLEPTISNWMKKTMNASEWQMGITWLPAFFPHILGVYITVKLAAKYPNYQWFYGAVGLVIIGASSCTIPACRNFEELIIPLCALCFGIALVDTALLPTLAFLVDIRYVSVYGSVYAIADISYSVAYALGPIMAGQIVHDLGFVQLNLGMGLVNILYAPALLFLRNVCQMKPSLSERNILLEEGPKGLYDTIIMEERKAAKEPHGSSSGNHSVHAVLSDQEGYSE
  
Inhibitor
Name:
BDBM50039612
Synonyms:
(1R,2R)-2-{3,4-dihydro-2H-spiro[naphthalene-1,4'-piperidine]-1'-yl}cyclohexan-1-ol | 2-spiro[1,2,3,4-tetrahydronaphthalene-1,4'-(hexahydropyridine)]-1-yl-(1R,2R)-cyclohexan-1-ol | CHEMBL87652
Type:
Small organic molecule
Emp. Form.:
C20H29NO
Mol. Mass.:
299.4504
SMILES:
O[C@@H]1CCCC[C@H]1N1CCC2(CCCc3ccccc23)CC1
Structure:
Search PDB for entries with ligand similarity: