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Target
Beta-1 adrenergic receptor
Ligand
BDBM50040066
Substrate
n/a
Meas. Tech.
ChEBML_216051
Ki
140±n/a nM
Citation
 Cecchetti, V; Fravolini, A; Schiaffella, F; Tabarrini, O; Bruni, G; Segre, G o-Chlorobenzenesulfonamidic derivatives of (aryloxy)propanolamines as beta-blocking/diuretic agents. J Med Chem 36:157-61 (1993) [PubMed]  Article 
Target
Name:
Beta-1 adrenergic receptor
Synonyms:
ADRB1 | ADRB1R | ADRB1_HUMAN | B1AR | Beta-1 adrenoceptor | adrenergic Beta1
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
51338.40
Organism:
Homo sapiens (Human)
Description:
P08588
Residue:
477
Sequence:
MGAGVLVLGASEPGNLSSAAPLPDGAATAARLLVPASPPASLLPPASESPEPLSQQWTAGMGLLMALIVLLIVAGNVLVIVAIAKTPRLQTLTNLFIMSLASADLVMGLLVVPFGATIVVWGRWEYGSFFCELWTSVDVLCVTASIETLCVIALDRYLAITSPFRYQSLLTRARARGLVCTVWAISALVSFLPILMHWWRAESDEARRCYNDPKCCDFVTNRAYAIASSVVSFYVPLCIMAFVYLRVFREAQKQVKKIDSCERRFLGGPARPPSPSPSPVPAPAPPPGPPRPAAAAATAPLANGRAGKRRPSRLVALREQKALKTLGIIMGVFTLCWLPFFLANVVKAFHRELVPDRLFVFFNWLGYANSAFNPIIYCRSPDFRKAFQRLLCCARRAARRRHATHGDRPRASGCLARPGPPPSPGAASDDDDDDVVGATPPARLLEPWAGCNGGAAADSDSSLDEPCRPGFASESKV
  
Inhibitor
Name:
BDBM50040066
Synonyms:
2-Chloro-5-{4-[2-hydroxy-3-(3-oxo-3,4-dihydro-2H-benzo[1,4]thiazin-8-yloxy)-propyl]-piperazin-1-yl}-benzenesulfonamide | CHEMBL40609
Type:
Small organic molecule
Emp. Form.:
C21H25ClN4O5S2
Mol. Mass.:
513.03
SMILES:
NS(=O)(=O)c1cc(ccc1Cl)N1CCN(CC(O)COc2cccc3NC(=O)CSc23)CC1
Structure:
Search PDB for entries with ligand similarity: