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TargetDopamine D2 receptor/Serotonin 2 (5-HT2) receptor
LigandBDBM50040082
Substrate/Competitorn/a
Meas. Tech.ChEBML_62557
Ki 1.5±n/a nM
Citation Chumpradit, SKung, MPBillings, JMach, RKung, HF Fluorinated and iodinated dopamine agents: D2 imaging agents for PET and SPECT. J Med Chem36:221-8 (1993) [PubMed]  Article
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Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor
Name:Dopamine D2 receptor and Serotonin 2a receptor (D2 and 5HT2a)
Synonyms:DOPAMINE D2 | DOPAMINE D2 Long | DOPAMINE D2 Short | DOPAMINE D2/D4 | DRD2 | Dopamine D2 receptor | Dopamine2-like
Type:G Protein-Coupled Receptor (GPCR)
Mol. Mass.:50931.60
Organism:Rattus norvegicus (rat)
Description:Receptor binding assays were performed using rat striatal membranes.
Residue:444
Sequence:
MDPLNLSWYDDDLERQNWSRPFNGSEGKADRPHYNYYAMLLTLLIFIIVFGNVLVCMAVS
REKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTA
SILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMIAIVWVLSFTISCPLLFGLNNTDQN
ECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRKRRKRVNTKRSSRAFRANLKTPL
KGNCTHPEDMKLCTVIMKSNGSFPVNRRRMDAARRAQELEMEMLSSTSPPERTRYSPIPP
SHHQLTLPDPSHHGLHSNPDSPAKPEKNGHAKIVNPRIAKFFEIQTMPNGKTRTSLKTMS
RRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNS
AVNPIIYTTFNIEFRKAFMKILHC
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  Blast E-value cutoff:
BDBM50040082
NameBDBM50040082
Synonyms:CHEMBL307023 | N-(1-Ethyl-pyrrolidin-2-ylmethyl)-2-iodo-6-methoxy-3-sulfamoyl-benzamide (iodosulpride) | N-(1-Ethyl-pyrrolidin-2-ylmethyl)-2-methoxy-5-sulfamoyl-benzamide(iodosulpiride)
TypeSmall organic molecule
Emp. Form.C15H22IN3O4S
Mol. Mass.467.322
SMILESCCN1CCC[C@H]1CNC(=O)c1c(I)c(ccc1OC)S(N)(=O)=O
Structure
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n/a