Reaction Details Report a problem with these data
Target
Kappa-type opioid receptor
Ligand
BDBM50040123
Substrate
n/a
Meas. Tech.
ChEMBL_223427 (CHEMBL845230)
IC50
0.077000±n/a nM
Citation
Kawasaki, AM; Knapp, RJ; Kramer, TH; Walton, A; Wire, WS; Hashimoto, S; Yamamura, HI; Porreca, F; Burks, TF; Hruby, VJ Design and synthesis of highly potent and selective cyclic dynorphin A analogs. 2. New analogs. J Med Chem 36:750-7 (1993) [PubMed] Article
More Info.:
Target
Name:
Kappa-type opioid receptor
Synonyms:
Kappa Opioid Receptor | OPIATE Kappa | OPRK1 | OPRK_CAVPO | Opiate Kappa 1 | mu/kappa opioid receptor
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
42744.99
Organism:
Cavia porcellus (domestic guinea pig)
Description:
P41144
Residue:
380
Sequence:
MGRRRQGPAQPASELPARNACLLPNGSAWLPGWAEPDGNGSAGPQDEQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIILGGTKVREDVDIIECSLQFPDDDYSWWDLFMKICVFVFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFIICWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPIKMRMERQSTSRVRNTVQDPAYMRNVDGVNKPV
Inhibitor
Name:
BDBM50040123
Synonyms:
CHEMBL438223 | HTry-Gly-Gly-Phe-Leu-Arg-Arg-lle-Arg-Pro-LysOH | Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Ile-Arg-Pro-Lys | [D-Pro-10]Dyn A-(1-11)
Type:
Small organic molecule
Emp. Form.:
C63H103N21O13
Mol. Mass.:
1362.6248
SMILES:
CC[C@H](C)[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)CNC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(O)=O