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Target
Kappa-type opioid receptor
Ligand
BDBM50040128
Substrate
n/a
Meas. Tech.
ChEMBL_223427 (CHEMBL845230)
IC50
81±n/a nM
Citation
 Kawasaki, AM; Knapp, RJ; Kramer, TH; Walton, A; Wire, WS; Hashimoto, S; Yamamura, HI; Porreca, F; Burks, TF; Hruby, VJ Design and synthesis of highly potent and selective cyclic dynorphin A analogs. 2. New analogs. J Med Chem 36:750-7 (1993) [PubMed]  Article 
Target
Name:
Kappa-type opioid receptor
Synonyms:
Kappa Opioid Receptor | OPIATE Kappa | OPRK1 | OPRK_CAVPO | Opiate Kappa 1 | mu/kappa opioid receptor
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
42744.99
Organism:
Cavia porcellus (domestic guinea pig)
Description:
P41144
Residue:
380
Sequence:
MGRRRQGPAQPASELPARNACLLPNGSAWLPGWAEPDGNGSAGPQDEQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIILGGTKVREDVDIIECSLQFPDDDYSWWDLFMKICVFVFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFIICWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPIKMRMERQSTSRVRNTVQDPAYMRNVDGVNKPV
  
Inhibitor
Name:
BDBM50040128
Synonyms:
CHEMBL384566 | Tyr-(D-ala)-Gly-Phe-c(Cys-Arg-Arg-Ile-Arg-Pro-Cys)
Type:
Small organic molecule
Emp. Form.:
C58H90N20O13S2
Mol. Mass.:
1339.591
SMILES:
CC[C@H](C)[C@H]1NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](CCCNC(N)=N)NC(=O)[C@@H](CSSC[C@@H](NC(=O)[C@H]2CCCN2C(=O)[C@H](CCCNC(N)=N)NC1=O)C(O)=O)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1
Structure:
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