Reaction Details Report a problem with these data
Target
Adenosine receptor A1
Ligand
BDBM50040372
Substrate
n/a
Meas. Tech.
ChEMBL_28668 (CHEMBL649066)
IC50
4100±n/a nM
Citation
 Buckle, DR; Arch, JR; Connolly, BJ; Fenwick, AE; Foster, KA; Murray, KJ; Readshaw, SA; Smallridge, M; Smith, DG Inhibition of cyclic nucleotide phosphodiesterase by derivatives of 1,3-bis(cyclopropylmethyl)xanthine. J Med Chem 37:476-85 (1994) [PubMed]  Article 
Target
Name:
Adenosine receptor A1
Synonyms:
AA1R_RAT | ADENOSINE A1 | ADENOSINE A1 high | ADENOSINE A1 low | Adenosine A1 receptor (A1) | Adenosine receptor | Adenosine receptors A1 | Adora1
Type:
Protein
Mol. Mass.:
36704.13
Organism:
Rattus norvegicus (rat)
Description:
n/a
Residue:
326
Sequence:
MPPYISAFQAAYIGIEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAILINIGPQTYFHTCLMVACPVLILTQSSILALLAIAVDRYLRVKIPLRYKTVVTQRRAAVAIAGCWILSLVVGLTPMFGWNNLSVVEQDWRANGSVGEPVIKCEFEKVISMEYMVYFNFFVWVLPPLLLMVLIYLEVFYLIRKQLNKKVSASSGDPQKYYGKELKIAKSLALILFLFALSWLPLHILNCITLFCPTCQKPSILIYIAIFLTHGNSAMNPIVYAFRIHKFRVTFLKIWNDHFRCQPKPPIDEDLPEEKAED
  
Inhibitor
Name:
BDBM50040372
Synonyms:
8-Amino-7-(4-chloro-benzenesulfonyl)-1,3-bis-cyclopropylmethyl-3,7-dihydro-purine-2,6-dione | CHEMBL357921
Type:
Small organic molecule
Emp. Form.:
C19H20ClN5O4S
Mol. Mass.:
449.911
SMILES:
Nc1nc2n(CC3CC3)c(=O)n(CC3CC3)c(=O)c2n1S(=O)(=O)c1ccc(Cl)cc1
Structure:
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