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Target
Tubulin beta chain
Ligand
BDBM50494620
Substrate
n/a
Meas. Tech.
ChEMBL_1278981 (CHEMBL3097627)
IC50
28000±n/a nM
Citation
 Nakamura, M; Kajita, D; Matsumoto, Y; Hashimoto, Y Design and synthesis of silicon-containing tubulin polymerization inhibitors: replacement of the ethylene moiety of combretastatin A-4 with a silicon linker. Bioorg Med Chem 21:7381-91 (2013) [PubMed]  Article 
Target
Name:
Tubulin beta chain
Synonyms:
Beta-tubulin | TBB_PIG | Tubulin beta chain
Type:
PROTEIN
Mol. Mass.:
49840.26
Organism:
Sus scrofa
Description:
ChEMBL_105107
Residue:
445
Sequence:
MREIVHIQAGQCGNQIGAKFWEVISDEHGIDPTGSYHGDSDLQLERINVYYNEAAGNKYVPRAILVDLEPGTMDSVRSGPFGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVVRKESESCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYPDRIMNTFSVVPSPKVSDTVVEPYNATLSVHQLVENTDETYCIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVPELTQQMFDAKNMMAACDPRHGRYLTVAAVFRGRMSMKEVDEQMLNVQNKNSSYFVEWIPNNVKTAVCDIPPRGLKMSATFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQDATADEQGEFEEEGEEDEA
  
Inhibitor
Name:
BDBM50494620
Synonyms:
CHEMBL3093568
Type:
Small organic molecule
Emp. Form.:
C17H22O5Si
Mol. Mass.:
334.4391
SMILES:
[#6]-[#8]-c1ccc(cc1-[#8])-[#14;v4](-[#6])-c1cc(-[#8]-[#6])c(-[#8]-[#6])c(-[#8]-[#6])c1
Structure:
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