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Target
Cysteinyl leukotriene receptor 1
Ligand
BDBM50041356
Substrate
n/a
Meas. Tech.
ChEMBL_152998 (CHEMBL759482)
Ki
0.380000±n/a nM
Citation
 Jacobs, RT; Bernstein, PR; Cronk, LA; Vacek, EP; Newcomb, LF; Aharony, D; Buckner, CK; Kusner, EJ Synthesis, structure-activity relationships, and pharmacological evaluation of a series of fluorinated 3-benzyl-5-indolecarboxamides: identification of 4-[[5-[((2R)-2-methyl-4,4,4-trifluorobutyl)carbamoyl]-1-methyl indol- 3-yl]methyl]-3-methoxy-N-[(2-methylphenyl)sulfonyl]benzamide, a potent, orall J Med Chem 37:1282-97 (1994) [PubMed]  Article 
Target
Name:
Cysteinyl leukotriene receptor 1
Synonyms:
CLTR1_CAVPO | CYSLTR1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
39007.58
Organism:
GUINEA PIG
Description:
Leukotriene D4 0 GUINEA PIG::Q2NNR5
Residue:
340
Sequence:
MDETGNPTIPPASNNTCYDSIDDFRNQVYSTLYSMISVVGFFGNGFVLYVLVKTYHEKSAFQVYMINLAVADLLCVCTLPLRVAYYVHKGIWLFGDFLCRLSTYALYVNLYCSIFFMTAMSFFRCVAIVFPVQNISLVTQKKARLVCIAIWMFVILTSSPFLMANTYKDEKNNTKCFEPPQDNQAKNYVLILHYVSLFIGFIIPFITIIVCYTMIIFTLLKSSMKKNLSSRKRAIGMIIVVTAAFLVSFMPYHIQRTIHLHFLHNKTKPCDSILRMQKSVVITLSLAASNCCFDPLLYFFSGGNFRRRLSTIRKYSLSSMTYIPKKKTSLPQKGKDICKE
  
Inhibitor
Name:
BDBM50041356
Synonyms:
1-Ethyl-3-[2-methoxy-4-(toluene-2-sulfonylaminocarbonyl)-benzyl]-1H-indole-5-carboxylic acid (4,4,4-trifluoro-2-methyl-butyl)-amide | CHEMBL26617
Type:
Small organic molecule
Emp. Form.:
C32H34F3N3O5S
Mol. Mass.:
629.69
SMILES:
CCn1cc(Cc2ccc(cc2OC)C(=O)NS(=O)(=O)c2ccccc2C)c2cc(ccc12)C(=O)NCC(C)CC(F)(F)F
Structure:
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