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Target
Type-1 angiotensin II receptor B
Ligand
BDBM50042238
Substrate
n/a
Meas. Tech.
ChEBML_34806
IC50
38±n/a nM
Citation
 Bernhart, CA; Perreaut, PM; Ferrari, BP; Muneaux, YA; Assens, JL; Clément, J; Haudricourt, F; Muneaux, CF; Taillades, JE; Vignal, MA A new series of imidazolones: highly specific and potent nonpeptide AT1 angiotensin II receptor antagonists. J Med Chem 36:3371-80 (1993) [PubMed]  Article 
Target
Name:
Type-1 angiotensin II receptor B
Synonyms:
AGTRB_RAT | AT3 | Agtr1 | Agtr1b | Angiotensin II AT1B | Angiotensin II receptor (AT-1) type-1 | Angiotensin II type 1b (AT-1b) receptor | At1b | Type-1B angiotensin II receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
40929.44
Organism:
RAT
Description:
Angiotensin II AT1B 0 RAT::P29089
Residue:
359
Sequence:
MTLNSSTEDGIKRIQDDCPKAGRHNYIFVMIPTLYSIIFVVGIFGNSLVVIVIYFYMKLKTVASVFLLNLALADLCFLLTLPLWAVYTAMEYRWPFGNHLCKIASASVSFNLYASVFLLTCLSIDRYLAIVHPMKSRLRRTMLVAKVTCIIIWLMAGLASLPAVIYRNVYFIENTNITVCAFHYESQNSTLPIGLGLTKNILGFVFPFLIILTSYTLIWKALKKAYKIQKNTPRNDDIFRIIMAIVLFFFFSWVPHQIFTFLDVLIQLGIIRDCEIADIVDTAMPITICIAYFNNCLNPLFYGFLGKKFKKYFLQLLKYIPPTAKSHAGLSTKMSTLSYRPSDNMSSSAKKSASFFEVE
  
Inhibitor
Name:
BDBM50042238
Synonyms:
4'-(6-Butyl-8-oxo-5,7-diaza-spiro[3.4]oct-5-en-7-ylmethyl)-biphenyl-2-carboxylic acid | CHEMBL113674
Type:
Small organic molecule
Emp. Form.:
C24H26N2O3
Mol. Mass.:
390.4748
SMILES:
CCCCC1=NC2(CCC2)C(=O)N1Cc1ccc(cc1)-c1ccccc1C(O)=O |t:4|
Structure:
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