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Target
Penicillin-binding protein 4
Ligand
BDBM50370584
Substrate
n/a
Meas. Tech.
ChEMBL_1289589 (CHEMBL3117908)
KON
19000 M-1s-1
Citation
 Dave, K; Palzkill, T; Pratt, RF Neutral ?-Lactams Inactivate High Molecular Mass Penicillin-Binding Proteins of Class B1, Including PBP2a of MRSA. ACS Med Chem Lett 5:154-7 (2014) [PubMed]  Article 
Target
Name:
Penicillin-binding protein 4
Synonyms:
2.4.1.129 | 3.4.16.4 | DD-transpeptidase | PBP 4 | PBPD_BACSU | Penicillin-binding protein 4 | Penicillin-insensitive transglycosylase | Penicillin-sensitive transpeptidase | Peptidoglycan TGase | pbpD
Type:
PROTEIN
Mol. Mass.:
70678.45
Organism:
Bacillus subtilis (strain 168)
Description:
ChEMBL_108030
Residue:
624
Sequence:
MTMLRKIIGWILLLCIIPLFAFTVIASGKEVKQMKSLDQVLDKNIDLKDISLVQNSYMYDRDGSLVSEIVSDHENRVLVPFNKIPEEVKQIFLTSEDRHFYEHKGFDFMGMVRATASNVKDKKIDQGASTITQQLSRNLYLSHERSFSRKLTELAYSYQLEKKYTKNEILEAYLNTIYFNNGVYGVGSAAQFYFSKPLKSLTVGEMAFICAIPNNPTLYDPLKHFDYTKSRQERLLKGLKDAGVITDKELKKAVKQKIKLDVEKREDKYPDYVSYVNDEFTQLVSESEGFDKRLQKASGKQKEKIENELSARVSTLMKDGVKIYTALDPYMQNQVVAQMNSKLPYADVQGGAAVINHQTHQIIALSGGKNYQKYDFNRAYQAYRQPGSSIKPLLDYGPYIEQTGATTSSTIDASKFCSKDYCPQNYNNRTYGTVTLDTAFKNSYNTPAIRMLDRVGIQKAFSYIEPYHFAKLVDSDYLLPAALGGFTNGMTPLEMTKAYTTFGNSGSYTPSHAITKVTDLKGKTLYKWNDKATQIFSVRTNMQLKKLMSSVVKSGTGKKAYFNAPYIGGKTGTSNDYHDMWFVGLTDTYTMGVWVGKDTPTSVEYLHSISPQLSIWKGTLQAAY
  
Inhibitor
Name:
BDBM50370584
Synonyms:
Beepen-VK | Betapen-VK | PENICILLIN V | Penapar-VK | Penicillin Phenoxymethyl
Type:
Small organic molecule
Emp. Form.:
C16H18N2O5S
Mol. Mass.:
350.39
SMILES:
CC1(C)S[C@@H]2[C@H](NC(=O)COc3ccccc3)C(=O)N2[C@H]1C(O)=O |r|
Structure:
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