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Target
Type-2 angiotensin II receptor
Ligand
BDBM50043044
Substrate
n/a
Meas. Tech.
ChEBML_35286
IC50
200±n/a nM
Citation
 VanAtten, MK; Ensinger, CL; Chiu, AT; McCall, DE; Nguyen, TT; Wexler, RR; Timmermans, PB A novel series of selective, non-peptide inhibitors of angiotensin II binding to the AT2 site. J Med Chem 36:3985-92 (1994) [PubMed]  Article 
Target
Name:
Type-2 angiotensin II receptor
Synonyms:
AGTR2_RAT | AT2 | Agtr2 | Angiotensin II AT2 | Angiotensin II receptor | Angiotensin II type 2 (AT-2) receptor | Type-2 angiotensin II receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
41346.62
Organism:
RAT
Description:
Angiotensin II AT2 0 0::P35351
Residue:
363
Sequence:
MKDNFSFAATSRNITSSLPFDNLNATGTNESAFNCSHKPADKHLEAIPVLYYMIFVIGFAVNIVVVSLFCCQKGPKKVSSIYIFNLAVADLLLLATLPLWATYYSYRYDWLFGPVMCKVFGSFLTLNMFASIFFITCMSVDRYQSVIYPFLSQRRNPWQASYVVPLVWCMACLSSLPTFYFRDVRTIEYLGVNACIMAFPPEKYAQWSAGIALMKNILGFIIPLIFIATCYFGIRKHLLKTNSYGKNRITRDQVLKMAAAVVLAFIICWLPFHVLTFLDALTWMGIINSCEVIAVIDLALPFAILLGFTNSCVNPFLYCFVGNRFQQKLRSVFRVPITWLQGKRETMSCRKSSSLREMDTFVS
  
Inhibitor
Name:
BDBM50043044
Synonyms:
2-Diphenylcarbamoyl-5-(4-methoxy-benzyl)-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid | CHEMBL131940
Type:
Small organic molecule
Emp. Form.:
C31H28N2O4
Mol. Mass.:
492.565
SMILES:
COc1ccc(Cc2cccc3CN(C(Cc23)C(O)=O)C(=O)N(c2ccccc2)c2ccccc2)cc1
Structure:
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