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Target
5-lipoxygenase
Ligand
BDBM50043365
Substrate
n/a
Meas. Tech.
ChEMBL_3983 (CHEMBL619256)
IC50
14000±n/a nM
Citation
 Müller, K; Gürster, D; Piwek, S; Wiegrebe, W Antipsoriatic anthrones with modulated redox properties. 1. Novel 10-substituted 1,8-dihydroxy-9(10H)-anthracenones as inhibitors of 5-lipoxygenase. J Med Chem 36:4099-107 (1994) [PubMed]  Article 
Target
Name:
5-lipoxygenase
Synonyms:
Arachidonate 5-lipoxygenase
Type:
PROTEIN
Mol. Mass.:
49994.23
Organism:
Bos taurus
Description:
ChEMBL_157766
Residue:
430
Sequence:
MPSYTVTVATGSQWFAGTDDYIYLSLVGSAGCSEKHLLDKPFYNDFERGAVDSYDVTVDEELGDIQLIKIEKRKYWFHDDWYLKYITVKTPCGDYIEFPCYRWISGEGEIVLRDGQAKLACDDQIHVLKQHRRKELETRQKQYRWMEWNPGFPLSIDAKCHKDLPRDIQFDSEKGVDFVLNYSKAMENLFINRFMHMFQSSWSDFADFEKIFVRISNTISERVMNHWQEDRMFGYQFLNGCNPVMIQRCLKLPDNLPVTTEMVECSLERQLTLEQEIEQGNIFIVDFKLLDGIDANKTDPCTLQFLAAPICLLYKNLANKIVPIAIQLNQVPGEENPIFLPSDAKYDWLLAKIWVRSSDFHVHQTITHLLRTHLVSEVFGIAMYRQLPAVHPIFKLLVAHVRFTIAINTKAREQLICEYGLFDKANATGG
  
Inhibitor
Name:
BDBM50043365
Synonyms:
1,8-Dihydroxy-10-[3-(3,4,5-trimethoxy-phenyl)-propionyl]-10H-anthracen-9-one | CHEMBL130360
Type:
Small organic molecule
Emp. Form.:
C26H24O7
Mol. Mass.:
448.4646
SMILES:
COc1cc(CCC(=O)C2c3cccc(O)c3C(=O)c3c(O)cccc23)cc(OC)c1OC
Structure:
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