Reaction Details Report a problem with these data
Target
Interstitial collagenase
Ligand
BDBM50043597
Substrate
n/a
Meas. Tech.
ChEMBL_49504 (CHEMBL662799)
IC50
>60000±n/a nM
Citation
Chapman, KT; Kopka, IE; Durette, PL; Esser, CK; Lanza, TJ; Izquierdo-Martin, M; Niedzwiecki, L; Chang, B; Harrison, RK; Kuo, DW Inhibition of matrix metalloproteinases by N-carboxyalkyl peptides. J Med Chem 36:4293-301 (1994) [PubMed] Article
More Info.:
Target
Name:
Interstitial collagenase
Synonyms:
CLG | Fibroblast collagenase | MMP1 | MMP1_HUMAN | Matrix metalloproteinase-1 | Matrix metalloproteinase-1 (MMP-1)
Type:
Enzyme
Mol. Mass.:
54010.26
Organism:
Homo sapiens (Human)
Description:
P03956
Residue:
469
Sequence:
MHSFPPLLLLLFWGVVSHSFPATLETQEQDVDLVQKYLEKYYNLKNDGRQVEKRRNSGPVVEKLKQMQEFFGLKVTGKPDAETLKVMKQPRCGVPDVAQFVLTEGNPRWEQTHLTYRIENYTPDLPRADVDHAIEKAFQLWSNVTPLTFTKVSEGQADIMISFVRGDHRDNSPFDGPGGNLAHAFQPGPGIGGDAHFDEDERWTNNFREYNLHRVAAHELGHSLGLSHSTDIGALMYPSYTFSGDVQLAQDDIDGIQAIYGRSQNPVQPIGPQTPKACDSKLTFDAITTIRGEVMFFKDRFYMRTNPFYPEVELNFISVFWPQLPNGLEAAYEFADRDEVRFFKGNKYWAVQGQNVLHGYPKDIYSSFGFPRTVKHIDAALSEENTGKTYFFVANKYWRYDEYKRSMDPGYPKMIAHDFPGIGHKVDAVFMKDGFFYFFHGTRQYKFDPKTKRILTLQKANSWFNCRKN
Inhibitor
Name:
BDBM50043597
Synonyms:
1N-[1-[1-benzylcarbamoyl-3-methyl-(1S)-butylcarbamoyl]-2-(1H-3-indolyl)-(1S)-ethyl]-2-amino-4-methyl-(2R)-pentanamide | CHEMBL339191
Type:
Small organic molecule
Emp. Form.:
C30H41N5O3
Mol. Mass.:
519.6782
SMILES:
CC(C)C[C@@H](N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)NCc1ccccc1