Reaction Details Report a problem with these data
Target
Thromboxane A2 receptor
Ligand
BDBM50003776
Substrate
n/a
Meas. Tech.
ChEMBL_209590 (CHEMBL814725)
IC50
6±n/a nM
Citation
 Soyka, R; Heckel, A; Nickl, J; Eisert, W; Müller, TH; Weisenberger, H 6,6-Disubstituted Hex-5-enoic acid derivatives as combined thromboxane A2 receptor antagonists and synthetase inhibitors. J Med Chem 37:26-39 (1994) [PubMed]  Article 
Target
Name:
Thromboxane A2 receptor
Synonyms:
Prostanoid TP receptor | TA2R_HUMAN | TBXA2R | TXA2-R | Thromboxane | Thromboxane A2 receptor | Thromboxane Beta
Type:
Enyzme
Mol. Mass.:
37445.28
Organism:
Homo sapiens (Human)
Description:
P21731
Residue:
343
Sequence:
MWPNGSSLGPCFRPTNITLEERRLIASPWFAASFCVVGLASNLLALSVLAGARQGGSHTRSSFLTFLCGLVLTDFLGLLVTGTIVVSQHAALFEWHAVDPGCRLCRFMGVVMIFFGLSPLLLGAAMASERYLGITRPFSRPAVASQRRAWATVGLVWAAALALGLLPLLGVGRYTVQYPGSWCFLTLGAESGDVAFGLLFSMLGGLSVGLSFLLNTVSVATLCHVYHGQEAAQQRPRDSEVEMMAQLLGIMVVASVCWLPLLVFIAQTVLRNPPAMSPAGQLSRTTEKELLIYLRVATWNQILDPWVYILFRRAVLRRLQPRLSTRPRSLSLQPQLTQRSGLQ
  
Inhibitor
Name:
BDBM50003776
Synonyms:
8-(4-Chloro-benzenesulfonylamino)-4-(3-pyridin-3-yl-propyl)-octanoic acid | CGS-22652 | CHEMBL65414
Type:
Small organic molecule
Emp. Form.:
C22H29ClN2O4S
Mol. Mass.:
452.995
SMILES:
OC(=O)CCC(CCCCNS(=O)(=O)c1ccc(Cl)cc1)CCCc1cccnc1
Structure:
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