Target
Dihydrofolate reductase
Ligand
BDBM50044421
Substrate
n/a
Meas. Tech.
ChEBML_54602
Ki
0.009±n/a nM
Citation
 DeGraw, JIColwell, WTPiper, JRSirotnak, FM Synthesis and antitumor activity of 10-propargyl-10-deazaaminopterin. J Med Chem 36:2228-31 (1993) [PubMed]  Article 
Target
Name:
Dihydrofolate reductase
Synonyms:
DYR_MOUSE | Dhfr
Type:
Enzyme
Mol. Mass.:
21608.82
Organism:
Mus musculus (Mouse)
Description:
n/a
Residue:
187
Sequence:
MVRPLNCIVAVSQNMGIGKNGDLPWPPLRNEFKYFQRMTTTSSVEGKQNLVIMGRKTWFSIPEKNRPLKDRINIVLSRELKEPPRGAHFLAKSLDDALRLIEQPELASKVDMVWIVGGSSVYQEAMNQPGHLRLFVTRIMQEFESDTFFPEIDLGKYKLLPEYPGVLSEVQEEKGIKYKFEVYEKKD
  
Inhibitor
Name:
BDBM50044421
Synonyms:
2-{4-[1-(2,4-Diamino-pteridin-6-ylmethyl)-butyl]-benzoylamino}-pentanedioic acid | CHEMBL72898
Type:
Small organic molecule
Emp. Form.:
C23H27N7O5
Mol. Mass.:
481.5044
SMILES:
CCCC(Cc1cnc2nc(N)nc(N)c2n1)c1ccc(cc1)C(=O)NC(CCC(O)=O)C(O)=O
Structure:
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