Reaction Details Report a problem with these data
Target
Dihydrofolate reductase
Ligand
BDBM50044421
Substrate
n/a
Meas. Tech.
ChEBML_54602
Ki
0.009±n/a nM
Citation
DeGraw, JI; Colwell, WT; Piper, JR; Sirotnak, FM Synthesis and antitumor activity of 10-propargyl-10-deazaaminopterin. J Med Chem 36:2228-31 (1993) [PubMed] Article
More Info.:
Target
Name:
Dihydrofolate reductase
Synonyms:
DYR_MOUSE | Dhfr
Type:
Enzyme
Mol. Mass.:
21608.82
Organism:
Mus musculus (Mouse)
Description:
n/a
Residue:
187
Sequence:
MVRPLNCIVAVSQNMGIGKNGDLPWPPLRNEFKYFQRMTTTSSVEGKQNLVIMGRKTWFSIPEKNRPLKDRINIVLSRELKEPPRGAHFLAKSLDDALRLIEQPELASKVDMVWIVGGSSVYQEAMNQPGHLRLFVTRIMQEFESDTFFPEIDLGKYKLLPEYPGVLSEVQEEKGIKYKFEVYEKKD