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Target
Cathepsin E
Ligand
BDBM50008139
Substrate
n/a
Meas. Tech.
ChEBML_45334
Ki
0.500000±n/a nM
Citation
 Rao, CM; Scarborough, PE; Kay, J; Batley, B; Rapundalo, S; Klutchko, S; Taylor, MD; Lunney, EA; Humblet, CC; Dunn, BM Specificity in the binding of inhibitors to the active site of human/primate aspartic proteinases: analysis of P2-P1-P1'-P2' variation. J Med Chem 36:2614-20 (1993) [PubMed]  Article 
Target
Name:
Cathepsin E
Synonyms:
3.4.23.34 | CATE_HUMAN | CTSE | Cathepsin E form I | Cathepsin E form II
Type:
Enzyme
Mol. Mass.:
43298.99
Organism:
Homo sapiens (Human)
Description:
P14091
Residue:
396
Sequence:
MKTLLLLLLVLLELGEAQGSLHRVPLRRHPSLKKKLRARSQLSEFWKSHNLDMIQFTESCSMDQSAKEPLINYLDMEYFGTISIGSPPQNFTVIFDTGSSNLWVPSVYCTSPACKTHSRFQPSQSSTYSQPGQSFSIQYGTGSLSGIIGADQVSVEGLTVVGQQFGESVTEPGQTFVDAEFDGILGLGYPSLAVGGVTPVFDNMMAQNLVDLPMFSVYMSSNPEGGAGSELIFGGYDHSHFSGSLNWVPVTKQAYWQIALDNIQVGGTVMFCSEGCQAIVDTGTSLITGPSDKIKQLQNAIGAAPVDGEYAVECANLNVMPDVTFTINGVPYTLSPTAYTLLDFVDGMQFCSSGFQGLDIHPPAGPLWILGDVFIRQFYSVFDRGNNRVGLAPAVP
  
Inhibitor
Name:
BDBM50008139
Synonyms:
2-[2-(Morpholine-4-sulfonylamino)-3-phenyl-propionylamino]-pent-4-enoic acid [1-cyclohexylmethyl-3,3-difluoro-3-(2-morpholin-4-yl-ethylcarbamoyl)-2-oxo-propyl]-amide | 2-[2-(Morpholine-4-sulfonylamino)-3-phenyl-propionylamino]-pent-4-enoic acid [1-cyclohexylmethyl-3,3-difluoro-3-(2-morpholin-4-yl-ethylcarbamoyl)-2-oxo-propyl]-amide; Hydrate; CH3SO3H | CHEMBL287423
Type:
Small organic molecule
Emp. Form.:
C35H52F2N6O8S
Mol. Mass.:
754.885
SMILES:
FC(F)(C(=O)NCCN1CCOCC1)C(=O)[C@H](CC1CCCCC1)NC(=O)[C@H](CC=C)NC(=O)[C@H](Cc1ccccc1)NS(=O)(=O)N1CCOCC1
Structure:
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