Reaction Details Report a problem with these data
Target
Kappa-type opioid receptor
Ligand
BDBM50045753
Substrate
n/a
Meas. Tech.
ChEMBL_220932 (CHEMBL874095)
Ki
41±n/a nM
Citation
 Zimmerman, DM; Leander, JD; Cantrell, BE; Reel, JK; Snoddy, J; Mendelsohn, LG; Johnson, BG; Mitch, CH Structure-activity relationships of trans-3,4-dimethyl-4-(3-hydroxyphenyl)piperidine antagonists for mu- and kappa-opioid receptors. J Med Chem 36:2833-41 (1993) [PubMed]  Article 
Target
Name:
Kappa-type opioid receptor
Synonyms:
Kappa Opioid Receptor | OPIATE Kappa | OPRK1 | OPRK_CAVPO | Opiate Kappa 1 | mu/kappa opioid receptor
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
42744.99
Organism:
Cavia porcellus (domestic guinea pig)
Description:
P41144
Residue:
380
Sequence:
MGRRRQGPAQPASELPARNACLLPNGSAWLPGWAEPDGNGSAGPQDEQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIILGGTKVREDVDIIECSLQFPDDDYSWWDLFMKICVFVFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFIICWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPIKMRMERQSTSRVRNTVQDPAYMRNVDGVNKPV
  
Inhibitor
Name:
BDBM50045753
Synonyms:
3-[3,4-Dimethyl-1-(4-phenyl-pentyl)-piperidin-4-yl]-phenol | CHEMBL95991
Type:
Small organic molecule
Emp. Form.:
C24H33NO
Mol. Mass.:
351.5249
SMILES:
CC(CCCN1CC[C@](C)([C@@H](C)C1)c1cccc(O)c1)c1ccccc1
Structure:
Search PDB for entries with ligand similarity: