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Target
Kappa-type opioid receptor
Ligand
BDBM50045749
Substrate
n/a
Meas. Tech.
ChEMBL_220933 (CHEMBL824000)
Ki
13±n/a nM
Citation
 Zimmerman, DM; Leander, JD; Cantrell, BE; Reel, JK; Snoddy, J; Mendelsohn, LG; Johnson, BG; Mitch, CH Structure-activity relationships of trans-3,4-dimethyl-4-(3-hydroxyphenyl)piperidine antagonists for mu- and kappa-opioid receptors. J Med Chem 36:2833-41 (1993) [PubMed]  Article 
Target
Name:
Kappa-type opioid receptor
Synonyms:
Kappa Opioid Receptor | OPIATE Kappa | OPRK1 | OPRK_CAVPO | Opiate Kappa 1 | mu/kappa opioid receptor
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
42744.99
Organism:
Cavia porcellus (domestic guinea pig)
Description:
P41144
Residue:
380
Sequence:
MGRRRQGPAQPASELPARNACLLPNGSAWLPGWAEPDGNGSAGPQDEQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIILGGTKVREDVDIIECSLQFPDDDYSWWDLFMKICVFVFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFIICWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPIKMRMERQSTSRVRNTVQDPAYMRNVDGVNKPV
  
Inhibitor
Name:
BDBM50045749
Synonyms:
3-[1-(3-Hydroxy-3-phenyl-propyl)-3,4-dimethyl-piperidin-4-yl]-phenol | CHEMBL98133
Type:
Small organic molecule
Emp. Form.:
C22H29NO2
Mol. Mass.:
339.4712
SMILES:
C[C@H]1CN(CCC(O)c2ccccc2)CC[C@@]1(C)c1cccc(O)c1
Structure:
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