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Target
Mu-type opioid receptor
Ligand
BDBM50045733
Substrate
n/a
Meas. Tech.
ChEMBL_221941 (CHEMBL881435)
Ki
0.560000±n/a nM
Citation
 Mitch, CH; Leander, JD; Mendelsohn, LG; Shaw, WN; Wong, DT; Cantrell, BE; Johnson, BG; Reel, JK; Snoddy, JD; Takemori, AE 3,4-Dimethyl-4-(3-hydroxyphenyl)piperidines: opioid antagonists with potent anorectant activity. J Med Chem 36:2842-50 (1993) [PubMed]  Article 
Target
Name:
Mu-type opioid receptor
Synonyms:
MOR-1 | MUOR1 | Mu-type opioid receptor (MOR) | OPIATE Mu | OPRM_RAT | Opiate non-selective | Opioid receptor B | Oprm1 | Ror-b
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
44503.11
Organism:
Rattus norvegicus (rat)
Description:
Competition binding assays were carried out using membrane preparations from transfected HN9.10 cells that constitutively expressed the mu opioid receptor.
Residue:
398
Sequence:
MDSSTGPGNTSDCSDPLAQASCSPAPGSWLNLSHVDGNQSDPCGLNRTGLGGNDSLCPQTGSPSMVTAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALITIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSTIEQQNSTRVRQNTREHPSTANTVDRTNHQLENLEAETAPLP
  
Inhibitor
Name:
BDBM50045733
Synonyms:
3-[3,4-Dimethyl-1-(3-thiophen-2-yl-propyl)-piperidin-4-yl]-phenol | 3-[3,4-Dimethyl-1-(3-thiophen-2-yl-propyl)-piperidin-4-yl]-phenol (+)-(3R), (4R)-41 | CHEMBL98507
Type:
Small organic molecule
Emp. Form.:
C20H27NOS
Mol. Mass.:
329.499
SMILES:
C[C@H]1CN(CCCc2cccs2)CC[C@@]1(C)c1cccc(O)c1
Structure:
Search PDB for entries with ligand similarity: