Reaction Details Report a problem with these data
Target
Platelet-activating factor receptor
Ligand
BDBM50045960
Substrate
n/a
Meas. Tech.
ChEBML_151691
IC50
170±n/a nM
Citation
 Carceller, E; Merlos, M; Giral, M; Almansa, C; Bartrolí, J; García-Rafanell, J; Forn, J Synthesis and structure-activity relationships of 1-acyl-4-((2-methyl-3-pyridyl)cyanomethyl)piperazines as PAF antagonists. J Med Chem 36:2984-97 (1993) [PubMed]  Article 
Target
Name:
Platelet-activating factor receptor
Synonyms:
PAF-R | PTAFR | PTAFR_CAVPO | Platelet activating factor receptor | Platelet-activating factor receptor
Type:
Protein
Mol. Mass.:
39005.63
Organism:
Cavia porcellus
Description:
n/a
Residue:
342
Sequence:
MELNSSSRVDSEFRYTLFPIVYSIIFVLGIIANGYVLWVFARLYPSKKLNEIKIFMVNLTVADLLFLITLPLWIVYYSNQGNWFLPKFLCNLAGCLFFINTYCSVAFLGVITYNRFQAVKYPIKTAQATTRKRGIALSLVIWVAIVAAASYFLVMDSTNVVSNKAGSGNITRCFEHYEKGSKPVLIIHICIVLGFFIVFLLILFCNLVIIHTLLRQPVKQQRNAEVRRRALWMVCTVLAVFVICFVPHHMVQLPWTLAELGMWPSSNHQAINDAHQVTLCLLSTNCVLDPVIYCFLTKKFRKHLSEKLNIMRSSQKCSRVTTDTGTEMAIPINHTPVNPIKN
  
Inhibitor
Name:
BDBM50045960
Synonyms:
CHEMBL318590 | {4-[3-(1,1-Dioxo-1lambda*6*-isothiazolidin-2-yl)-3-phenyl-propionyl]-piperazin-1-yl}-(2-methyl-pyridin-3-yl)-acetonitrile
Type:
Small organic molecule
Emp. Form.:
C24H29N5O3S
Mol. Mass.:
467.584
SMILES:
Cc1ncccc1C(C#N)N1CCN(CC1)C(=O)CC(N1CCCS1(=O)=O)c1ccccc1
Structure:
Search PDB for entries with ligand similarity: