Reaction Details Report a problem with these data
Target
Platelet-activating factor receptor
Ligand
BDBM50045980
Substrate
n/a
Meas. Tech.
ChEBML_151691
IC50
46±n/a nM
Citation
 Carceller, E; Merlos, M; Giral, M; Almansa, C; Bartrolí, J; García-Rafanell, J; Forn, J Synthesis and structure-activity relationships of 1-acyl-4-((2-methyl-3-pyridyl)cyanomethyl)piperazines as PAF antagonists. J Med Chem 36:2984-97 (1993) [PubMed]  Article 
Target
Name:
Platelet-activating factor receptor
Synonyms:
PAF-R | PTAFR | PTAFR_CAVPO | Platelet activating factor receptor | Platelet-activating factor receptor
Type:
Protein
Mol. Mass.:
39005.63
Organism:
Cavia porcellus
Description:
n/a
Residue:
342
Sequence:
MELNSSSRVDSEFRYTLFPIVYSIIFVLGIIANGYVLWVFARLYPSKKLNEIKIFMVNLTVADLLFLITLPLWIVYYSNQGNWFLPKFLCNLAGCLFFINTYCSVAFLGVITYNRFQAVKYPIKTAQATTRKRGIALSLVIWVAIVAAASYFLVMDSTNVVSNKAGSGNITRCFEHYEKGSKPVLIIHICIVLGFFIVFLLILFCNLVIIHTLLRQPVKQQRNAEVRRRALWMVCTVLAVFVICFVPHHMVQLPWTLAELGMWPSSNHQAINDAHQVTLCLLSTNCVLDPVIYCFLTKKFRKHLSEKLNIMRSSQKCSRVTTDTGTEMAIPINHTPVNPIKN
  
Inhibitor
Name:
BDBM50045980
Synonyms:
4-{4-[Cyano-(2-methyl-pyridin-3-yl)-methyl]-piperazin-1-yl}-4-oxo-2,2-diphenyl-butyric acid ethyl ester | CHEMBL103533
Type:
Small organic molecule
Emp. Form.:
C30H32N4O3
Mol. Mass.:
496.6001
SMILES:
CCOC(=O)C(CC(=O)N1CCN(CC1)C(C#N)c1cccnc1C)(c1ccccc1)c1ccccc1
Structure:
Search PDB for entries with ligand similarity: