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Target
Platelet-activating factor receptor
Ligand
BDBM50045989
Substrate
n/a
Meas. Tech.
ChEMBL_151692 (CHEMBL760442)
IC50
15200±n/a nM
Citation
 Carceller, E; Merlos, M; Giral, M; Almansa, C; Bartrolí, J; García-Rafanell, J; Forn, J Synthesis and structure-activity relationships of 1-acyl-4-((2-methyl-3-pyridyl)cyanomethyl)piperazines as PAF antagonists. J Med Chem 36:2984-97 (1993) [PubMed]  Article 
Target
Name:
Platelet-activating factor receptor
Synonyms:
PAF-R | PTAFR | PTAFR_CAVPO | Platelet activating factor receptor | Platelet-activating factor receptor
Type:
Protein
Mol. Mass.:
39005.63
Organism:
Cavia porcellus
Description:
n/a
Residue:
342
Sequence:
MELNSSSRVDSEFRYTLFPIVYSIIFVLGIIANGYVLWVFARLYPSKKLNEIKIFMVNLTVADLLFLITLPLWIVYYSNQGNWFLPKFLCNLAGCLFFINTYCSVAFLGVITYNRFQAVKYPIKTAQATTRKRGIALSLVIWVAIVAAASYFLVMDSTNVVSNKAGSGNITRCFEHYEKGSKPVLIIHICIVLGFFIVFLLILFCNLVIIHTLLRQPVKQQRNAEVRRRALWMVCTVLAVFVICFVPHHMVQLPWTLAELGMWPSSNHQAINDAHQVTLCLLSTNCVLDPVIYCFLTKKFRKHLSEKLNIMRSSQKCSRVTTDTGTEMAIPINHTPVNPIKN
  
Inhibitor
Name:
BDBM50045989
Synonyms:
4-{4-[Cyano-(2-methyl-pyridin-3-yl)-methyl]-piperazin-1-yl}-N-methyl-4-oxo-2-phenyl-butyramide | CHEMBL103546
Type:
Small organic molecule
Emp. Form.:
C23H27N5O2
Mol. Mass.:
405.4928
SMILES:
CNC(=O)C(CC(=O)N1CCN(CC1)C(C#N)c1cccnc1C)c1ccccc1
Structure:
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