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TargetCoagulation factor VII/Tissue factor
LigandBDBM50498198
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1472450
Ki 13000000±n/a nM
Citation Cheney, DLBozarth, JMMetzler, WJMorin, PEMueller, LNewitt, JANirschl, AHRendina, ARTamura, JKWei, AWen, XWurtz, NRSeiffert, DAWexler, RRPriestley, ES Discovery of novel P1 groups for coagulation factor VIIa inhibition using fragment-based screening. J Med Chem58:2799-808 (2015) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Coagulation factor VII/Tissue factor
Name:Coagulation factor VII/Tissue factor
Synonyms:Coagulation factor III/Factor VIIa (fVIIa) | Coagulation factor III/VII | Coagulation factor VII/tissue factor
Type:n/a
Mol. Mass.:n/a
Description:ASSAY_ID of EBI is 69535
Components:This complex has 2 components.
Component 1
Name:Tissue factor
Synonyms:CD_antigen=CD142 | Coagulation factor III | Coagulation factor VII/tissue factor | TF | Thromboplastin | Tissue factor
Type:PROTEIN
Mol. Mass.:33067.61
Organism:Homo sapiens (Human)
Description:ChEMBL_936735
Residue:295
Sequence:
METPAWPRVPRPETAVARTLLLGWVFAQVAGASGTTNTVAAYNLTWKSTNFKTILEWEPK
PVNQVYTVQISTKSGDWKSKCFYTTDTECDLTDEIVKDVKQTYLARVFSYPAGNVESTGS
AGEPLYENSPEFTPYLETNLGQPTIQSFEQVGTKVNVTVEDERTLVRRNNTFLSLRDVFG
KDLIYTLYYWKSSSSGKKTAKTNTNEFLIDVDKGENYCFSVQAVIPSRTVNRKSTDSPVE
CMGQEKGEFREIFYIIGAVVFVVIILVIILAISLHKCRKAGVGQSWKENSPLNVS
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Component 2
Name:Coagulation factor VII
Synonyms:Eptacog alfa | Factor VIIa | Factor VIIa (fVIIa) | Proconvertin | SPCA | Thrombin and coagulation factor VII | serum prothrombin conversion accelerator
Type:Enzyme
Mol. Mass.:51599.89
Organism:Homo sapiens (Human)
Description:n/a
Residue:466
Sequence:
MVSQALRLLCLLLGLQGCLAAGGVAKASGGETRDMPWKPGPHRVFVTQEEAHGVLHRRRR
ANAFLEELRPGSLERECKEEQCSFEEAREIFKDAERTKLFWISYSDGDQCASSPCQNGGS
CKDQLQSYICFCLPAFEGRNCETHKDDQLICVNENGGCEQYCSDHTGTKRSCRCHEGYSL
LADGVSCTPTVEYPCGKIPILEKRNASKPQGRIVGGKVCPKGECPWQVLLLVNGAQLCGG
TLINTIWVVSAAHCFDKIKNWRNLIAVLGEHDLSEHDGDEQSRRVAQVIIPSTYVPGTTN
HDIALLRLHQPVVLTDHVVPLCLPERTFSERTLAFVRFSLVSGWGQLLDRGATALELMVL
NVPRLMTQDCLQQSRKVGDSPNITEYMFCAGYSDGSKDSCKGDSGGPHATHYRGTWYLTG
IVSWGQGCATVGHFGVYTRVSQYIEWLQKLMRSEPRPGVLLRAPFP
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BDBM50498198
NameBDBM50498198
Synonyms:CHEBI:48220 | DICHLOROBENZYL ALCOHOL | Dichlorobenzyl alcohol
TypeSmall organic molecule
Emp. Form.C7H6Cl2O
Mol. Mass.177.028
SMILESOCc1ccc(Cl)cc1Cl
Structure
n/a